Connexin 43
Connexin 43 - Related Videos
09:20
Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption
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Cited by 6 •
2019
Here, we present a mechanics-based protocol to disrupt the gap junction connexin 43 and measure the subsequent impact this has on endothelial biomechanics via observation of tractions and intercellular stresses.
13:31
Novel Atomic Force Microscopy Based Biopanning for Isolation of Morphology Specific Reagents against TDP-43 Variants in Amyotrophic Lateral Sclerosis
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Cited by 17 •
2015
Using atomic force microscopy in combination with biopanning technology we created a negative and positive biopanning system to acquire antibodies against disease-specific protein variants present in any biological material, even at low concentrations. We were successful in obtaining antibodies to TDP-43 protein variants involved in Amyotrophic Lateral Sclerosis.
07:07
Measuring Glucose Uptake in Drosophila Models of TDP-43 Proteinopathy
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Cited by 3 •
2021
Glucose uptake is increased in Drosophila motor neurons affected by TAR DNA binding protein (TDP-43) proteinopathy, as indicated by a FRET-based, genetically encoded glucose sensor.
06:06
Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43
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Cited by 2 •
2020
Here, we describe a S. pneumoniae serotype 1 strain 519/43 that can be genetically modified by using its ability to naturally acquire DNA and a suicide-plasmid. As proof of principle, an isogenic mutant in the pneumolysin (ply) gene was made.
07:14
Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
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2022
We describe a protocol to induce phase transition of TAR DNA-binding protein 43 (TDP-43) by light in the spinal motor neurons using zebrafish as a model.
FAQs
Cx43 helps neighboring cardiac cells exchange ions and small signaling molecules through direct cytoplasmic communication. This coordinated transfer supports electrical conduction across tissue, so changes in the protein’s expression, localization, or channel activity can disturb communication and are associated with arrhythmias. Its medical importance therefore extends beyond protein presence to proper placement and function.
The amount of Cx43 alone does not fully describe its biological effect. Localization indicates where the protein is positioned within tissue, while channel activity reflects whether communication pathways are functioning. These properties can change independently, making it important for medical research to examine expression, distribution, and activity together when investigating abnormal conduction, healing, or remodeling.
Cx43 participates in several forms of tissue coordination, including wound repair, inflammation, and tissue remodeling. Altered behavior in these settings has been associated with impaired healing and fibrosis. This broad involvement makes Cx43 relevant to diseases in which communication between neighboring cells affects how tissue responds to injury and reorganizes during recovery or progression.
Diagnostic research can evaluate whether Cx43 expression, localization, or channel activity differs from the expected tissue state. Examining these features may help connect abnormal cell-to-cell communication with conditions such as arrhythmias, impaired healing, or fibrosis. The combined assessment is useful because disease-related changes may involve protein amount, placement, function, or several of these properties.
Researchers may investigate Cx43 when studying cardiac electrical conduction, wound repair, inflammation, fibrosis, or broader tissue remodeling. These applications reflect distinct clinical questions: whether altered communication contributes to abnormal rhythm, whether repair is impaired, or whether tissue organization changes during disease. The protein is consequently relevant to both disease characterization and the search for therapeutic strategies.
Because altered Cx43 expression, localization, or channel activity is associated with several pathological changes, researchers can consider these properties as potential points for therapeutic investigation. A study might relate a change in Cx43 to arrhythmia, impaired healing, or fibrosis, then evaluate whether modifying the relevant process could improve tissue coordination. The overview supports this as a development objective, not a guaranteed treatment outcome.