Gastrointestinal Regulation
Gastrointestinal Regulation - Related Videos
08:15
Gastrointestinal Motility Monitor (GIMM)
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Cited by 35 •
2010
Evaluation of colonic motility in the guinea pig distal colon with the Gastrointestinal Motility Monitor (GIMM) is a straightforward and simple to learn approach to quantitatively evaluate propulsive motility in the gastrointestinal tract.
07:41
Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
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Cited by 59 •
2016
This article describes a video imaging technique and high-resolution spatiotemporal mapping to identify changes in the neural regulation of colonic motility in adult mice. Subtle effects on gastrointestinal (GI) function can be detected using this approach in isolated tissue preparations to advance our understanding of GI disease.
06:02
Isolation of CD 90+ Fibroblast/Myofibroblasts from Human Frozen Gastrointestinal Specimens
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Cited by 17 •
2016
Here, a protocol to isolate and establish primary fibroblast/myofibroblast (MF) cultures from frozen gastric, small intestinal, and colonic tissue-yielding cells with a MF phenotype-is presented. These cells express CD90, α-SMA and vimentin. MFs can be used for a variety of functional assays including enzymatic activity and cytokine production.
06:04
Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease
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Cited by 51 •
2016
This protocol describes the use of excised intestinal tissue preparations or "intestinal sacs" as an ex vivo model of intestinal barrier function. This model may be used to assess integrity of both the epithelial barrier and the mucous gel layer at specific intestinal sites in animal models of digestive disease.
08:22
Using an Ingestible Telemetric Temperature Pill to Assess Gastrointestinal Temperature During Exercise
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Cited by 38 •
2015
This study describes an accurate, reliable and non-invasive technique to continuously measure gastrointestinal temperature during exercise. The ingestible telemetric temperature pill is suitable to measure gastrointestinal temperature in laboratory settings as well as in field based settings.
FAQs
Control is distributed across several interacting systems rather than assigned to a single controller. The enteric nervous system coordinates activity within the digestive tract, autonomic nerves connect regulation with broader neural control, and gastrointestinal hormones and local signals adjust responses to conditions inside the lumen. Their interaction allows motility and glandular activity to change together as digestive demands shift.
Mechanical distension provides information about the physical state of the tract, while luminal contents provide information about what is being processed. Gastrointestinal regulation uses these signals to adjust smooth muscle activity and glandular function. This matters because the gut must respond differently as contents move through it, supporting appropriate propulsion, mixing, digestion, and absorption.
Propulsion moves material through the tract, whereas mixing promotes contact between contents and the digestive surfaces. At the same time, regulated glandular activity supports digestion, and coordinated handling supports absorption. Keeping these processes aligned prevents movement, secretion, and nutrient processing from operating independently, thereby improving the effectiveness of food and fluid processing.
The digestive tract does not operate in isolation. Its regulatory networks include autonomic nerves and gastrointestinal hormones that participate in communication between the gut and other organs. This broader signaling context helps explain why gastrointestinal regulation is relevant beyond local digestion and why it contributes to research on digestive and systemic disease.
These disorders can be examined as problems involving the coordinated control of gastrointestinal activity. Studying regulation helps researchers and clinicians consider how altered motility, secretion, or responses to luminal conditions may affect digestive function. The framework therefore supports investigation and treatment of reflux, constipation, diarrhea, and impaired gut motility without reducing them to a single mechanism.
Research can assess whether digestive processes remain coordinated across motility, secretion, blood flow, digestion, and absorption. It can also examine how the gut responds to food, fluids, luminal contents, and distension, and how those responses communicate with other organs. These outcomes provide context for understanding digestive disorders and their connections with systemic disease.