Prosthesis Patient Mismatch
Prosthesis Patient Mismatch - Related Videos
01:48
Mismatch Repair
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Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.The Mutator Protein Family Plays a Key Role in DNA Mismatch RepairThe human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
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Mismatch Repair
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Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes. The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
01:48
Mismatch Repair
0 Views •
2026
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.The Mutator Protein Family Plays a Key Role in DNA Mismatch RepairThe human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
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Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
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Full-root aortic valve replacement by stentless aortic xenograft is a viable option in patients with small aortic roots. We describe, a technique for the full-root implantation of stentless aortic xenografts, with emphasis on the management of the proximal suture line and coronary anastomoses, and discuss its limitations and alternative options.
08:08
Oscillation and Reaction Board Techniques for Estimating Inertial Properties of a Below-knee Prosthesis
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Cited by 35 •
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Body segmental inertial properties are required for inverse dynamics modeling. Using an oscillation and reaction board technique, inertial properties of below-knee prostheses were measured. Using direct measures of prosthesis inertia in the inverse dynamics model of the prosthetic leg resulted in lower magnitudes of resultant joint forces and moments.
FAQs
The same effective orifice area may provide different hemodynamic performance in recipients of different body sizes. Indexed effective orifice area helps relate the prosthetic opening to the individual recipient rather than interpreting the opening in isolation. This patient-specific assessment supports more meaningful evaluation of whether the implanted valve can support the expected forward blood flow.
A normally functioning prosthesis can still create higher transvalvular gradients when its effective opening is too small for the recipient. Blood must pass through that limited area, increasing the pressure difference across the valve. This mechanism distinguishes a size-related hemodynamic limitation from a prosthesis that is malfunctioning, even though both may produce abnormal pressure measurements.
The distinction depends on combining hemodynamic findings with evidence about prosthetic performance. Mismatch occurs despite normal prosthetic function, whereas the concern is different when imaging or other evaluation indicates that the prosthesis itself is not functioning normally. Reviewing indexed effective orifice area, pressure measurements, and imaging together helps clinicians interpret elevated gradients more accurately.
No single measurement should determine the assessment in isolation. Clinicians interpret the indexed effective orifice area alongside the patient’s symptoms, imaging findings, and pressure measurements after implantation. This integrated approach connects the calculated valve opening with observed hemodynamics and clinical status, helping determine whether the prosthesis is providing the expected improvement in forward blood flow.
Postoperative evaluation begins with assessment of the implanted valve and calculation of its indexed effective orifice area. Clinicians then review imaging, pressure measurements, and symptoms to place the result in clinical context. This workflow is applicable after valve implantation and helps identify whether a size-related limitation may be affecting the expected hemodynamic benefit.
Recognizing the possibility of mismatch provides relevant information when clinicians evaluate prosthesis options for an individual recipient. Because the effective opening must be considered in relation to body size, prosthesis selection should account for the expected hemodynamic result rather than valve implantation alone. This consideration is relevant to both surgical and transcatheter aortic valve replacement.
The issue is relevant across both surgical and transcatheter aortic valve replacement because either approach requires evaluation of the implanted valve’s hemodynamic performance. Identifying a size-related limitation supports postoperative assessment and management, particularly when pressure measurements, imaging, symptoms, or forward blood flow do not show the expected improvement after replacement.