Topical Heart Cooling
Topical Heart Cooling - Related Videos
08:15
Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion
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2025
Donor heart preservation is a major determinant of success in heart transplantation. Technological advances have led to optimizing the conditions of preservation, along with a more accurate assessment of the donor heart before transplantation. We herein describe two innovative technologies currently applied for cardiac preservation: uniform cooling preservation and normothermic ex-situ heart perfusion.
02:44
Heating and Cooling Curves
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2020
When a substance—isolated from its environment—is subjected to heat changes, corresponding changes in temperature and phase of the substance is observed; this is graphically represented by heating and cooling curves. For instance, the addition of heat raises the temperature of a solid; the amount of heat absorbed depends on the heat capacity of the solid (q = mcsolidΔT). According to thermochemistry, the relation between the amount of heat absorbed or released by a substance, q, and its...
07:27
Implantation of Total Artificial Heart in Congenital Heart Disease
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Cited by 40 •
2014
This is a case report of a patient with congenitally corrected transposition of the great arteries (CCTGA) who received a total artificial heart (TAH) as a bridge to heart transplant. The TAH was successfully implanted with modifications to accommodate the patient's congenitally malformed heart.
04:43
Topical Testing Assay: A Technique to Evaluate the Insecticidal Potential of Dopamine Receptor Antagonists on Adult Female Mosquitoes by Topical Application
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2025
In this video, we demonstrate the topical testing assay to determine the toxicity of a potential insecticide on adult female mosquitoes. Using a dopamine receptor antagonist that causes lethal inhibition of neurotransmission in mosquitoes, this method describes a way to evaluate the toxic effects of insecticides upon topical application.
06:51
Recovery of Adult Zebrafish Hearts for High-throughput Applications
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Cited by 16 •
2014
Use of zebrafish for cardiovascular research is expanding towards research on adult hearts. For these applications, quick and simple isolation of cardiac tissues is key to avoid post-mortem changes and to obtain an adequate number of samples. Here, we describe a fast and reproducible method for dissecting adult zebrafish hearts.
FAQs
Lowering myocardial temperature slows cellular metabolism, so heart tissue requires less oxygen while circulation is reduced or temporarily interrupted. This metabolic slowdown can help the myocardium tolerate ischemic stress, meaning injury caused by inadequate blood flow. The protective effect is therefore linked to temperature reduction and the heart’s reduced metabolic workload during vulnerable periods.
When blood flow is interrupted, the myocardium has less access to oxygen needed for normal cellular activity. Cooling reduces the rate of that activity, lowering oxygen demand during the interruption. By decreasing the mismatch between oxygen needs and available blood flow, Topical Heart Cooling may help limit tissue injury and support preservation of heart function.
Topical cooling can serve as one component of a broader myocardial-protection approach rather than functioning as the sole protective measure. Its direct effect on heart temperature may add metabolic protection during cardiac arrest or reduced circulation. Combining it with other methods allows procedure design and research to consider several ways of preserving the myocardium under ischemic stress.
The cooling material may be a cooled solution, a cooling pad, or another material placed directly on the heart’s surface. These options share the goal of transferring cooling to the myocardium during the relevant procedural period. The overview supports these material categories, but it does not specify particular temperatures, application times, equipment models, or handling protocols.
It may be considered during cardiac surgery and related procedures when circulation is reduced or the heart is arrested. Those conditions create periods in which myocardial oxygen supply is limited, making metabolic protection relevant. Its use supports planning around vulnerable intervals and may complement other measures intended to reduce tissue injury and preserve subsequent heart function.
Studies can examine whether reducing myocardial temperature is associated with less tissue injury during ischemic stress and better preservation of heart function. Researchers may also evaluate how the technique fits within procedure designs that include reduced circulation or cardiac arrest. The scientific context centers on myocardial protection, oxygen demand, cellular metabolism, and recovery of cardiac performance.