Alveolar Recruitment
Alveolar Recruitment - Related Videos
11:26
Harvesting Murine Alveolar Macrophages and Evaluating Cellular Activation Induced by Polyanhydride Nanoparticles
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Cited by 16 •
2012
Herein, we describe protocols for harvesting murine alveolar macrophages, which are resident innate immune cells in the lung, and examining their activation in response to co-culture with polyanhydride nanoparticles.
09:04
Assessing Anti-fungal Activity of Isolated Alveolar Macrophages by Confocal Microscopy
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Cited by 3 •
2014
A method to evaluate the ability of isolated mouse alveolar macrophages to control the growth of phagocytosed Aspergillus spores by confocal microscopy.
07:47
Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis
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Cited by 7 •
2016
Here we describe the model and approach to study functions of pulmonary alveolar macrophages in cancer metastasis. To demonstrate the role of these cells in metastasis, the syngeneic (4T1) model of breast cancer in conjunction with the depletion of alveolar macrophage with clodronate liposomes was used.
01:26
Alveoli and Alveolar Ducts
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2024
The respiratory zone of the human body, which stands in contrast to the conducting zone, comprises the structures that actively participate in the exchange of gases. The initiation of this zone is marked by the terminal bronchioles converging into respiratory bronchioles, the tiniest bronchiole classification. The respiratory bronchioles give way to the alveolar ducts that opens into a congregation of alveoli. Actively involved in gas exchange, alveoli resemble tiny sacs similar to clusters of...
05:52
An In Vitro Flow Investigation of the Effect of Stromal Cells on Leukocyte Recruitment
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2025
The video demonstrates a method for investigating the impact of stromal cells on leukocyte recruitment. In a parallel plate flow chamber model, pro-inflammatory cytokines induce the expression of adhesion receptors by endothelial cells, facilitating neutrophil recruitment and migration. The cross-talk between stromal cells and endothelial cells diminishes neutrophil recruitment to the endothelial cells.
FAQs
Transpulmonary pressure provides the distending force that can reopen collapsed or poorly aerated alveoli. During a recruitment maneuver, increasing airway pressure raises this pressure and can improve the amount of aerated lung available for gas exchange. The subsequent use of sufficient positive end-expiratory pressure is important because reopening without maintaining alveolar patency may not provide a sustained benefit.
Positive end-expiratory pressure helps preserve the newly improved aeration after alveoli have been opened. By supporting alveolar patency at the end of expiration, it can help sustain better gas exchange and limit the return of poorly aerated regions. Its role therefore complements, rather than replaces, the pressure increase used for recruitment.
Both approaches increase airway pressure to promote reopening, but they apply that increase differently. A sustained maneuver maintains a higher pressure for a period, whereas a stepwise maneuver raises pressure in stages. The provided context identifies both as recruitment options but does not establish that one approach is universally superior to the other.
Conceptually, the maneuver has two linked stages: first, airway pressure is increased in a sustained or stepwise fashion to promote reopening; second, sufficient positive end-expiratory pressure is applied to help maintain that state. This sequence connects the immediate mechanical action of recruitment with the longer-term goal of improved aeration and gas exchange.
Clinicians may consider alveolar recruitment when mechanical ventilation is accompanied by atelectasis or acute respiratory failure, especially when poor aeration contributes to impaired oxygenation. The intended physiological outcomes are improved lung aeration, better gas exchange, and reduced intrapulmonary shunting. These outcomes explain its relevance as a strategy within respiratory support.
The pressure needed to reopen alveoli can become excessive. Overly high pressures may produce alveolar overdistension, impair circulation, or cause hemodynamic instability. Consequently, the potential gains in aeration and oxygenation must be weighed against pressure-related harm, making the balance between effective recruitment and excessive distending pressure central to its medical use.