Urethral Injury

Urethral injury is damage to the tube that carries urine from the bladder out of the body, and it can result from blunt or penetrating trauma, pelvic fracture, or instrumentation. When the urethral wall is torn or disrupted, urine and blood may escape into surrounding tissues, while inflammation and scar formation during healing can narrow the lumen and cause urethral stricture. In medicine, recognizing signs such as blood at the meatus, difficulty urinating, or urinary retention guides evaluation, often with retrograde urethrography before catheterization when injury is suspected, and helps clinicians select urinary diversion, endoscopic management, or surgical repair.

Urethral Injury - Related Videos

Research

JoVE Journal - Medicine

Urethral Stricture Induction Followed by Buccal Mucosa Graft Urethroplasty in a Rat Model

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Cited by 3 •

2023

In the present protocol, a urethral stricture induction was developed in Wistar rats, followed by urethral reconstruction with a buccal mucosa graft. A retrograde urethrogram and laser Doppler assessment were performed, validating urethral reconstruction (after stricture formation) and graft placement.

Nerve-sparing Mid-urethral Obstruction (NeMO) in Female Small Rodents

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Cited by 7 •

2017

Traditional modeling of partial bladder outlet obstruction in rodents is fraught with animal mortality. A denervation injury from dissection around the proximal urethra and bladder neck is also of major concern. We developed and evaluated a safe and reliable mid-urethral obstruction model, avoiding the shortcomings of the traditional model.

Research

JoVE Journal - Biology
Free Sample

In Vivo Telemetry to Record Long-Term Cardiovascular Parameters, Temperature, and Activity in Spinal Cord Injury Rat Models

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2026

This article presents a step-by-step protocol for the placement of an in vivo telemetric implant in the descending aorta of rats, allowing continuous and long-term monitoring of cardiovascular parameters, core body temperature, and animal activity before and after severe high-thoracic spinal cord injury.

Research

JoVE Journal - Medicine
Free Sample

Controlled Cervical Laceration Injury in Mice

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Cited by 17 •

2013

A novel technique to create a reproducible in vivo model of cervical spinal cord laceration injury in the mouse is described. This technique is based on spine stabilization by fixation of the cervical facets and laceration of the spinal cord using an oscillating blade with an accuracy of ±0.01 mm.

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury

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Cited by 16 •

2017

Athletes absorb several hundred mild traumatic brain injuries (mTBI)/concussions every year; however, the consequence of these on the brain is poorly understood. Therefore, an animal model of single and repetitive mTBI that consistently replicates clinically relevant symptoms provides the means to advance the study of mTBI and concussion.

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