I7 Muscle Lesion
I7 Muscle Lesion - Related Videos
05:38
A Minimally Invasive Lesion Technique for Muscles Intrinsic to the Odontophore of Aplysia californica
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2019
Here we present a protocol for minimally invasive surgical lesioning of muscles intrinsic to the feeding apparatus of the marine mollusk Aplysia californica to understand the roles of these muscles during feeding behavior.
06:43
Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
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Cited by 51 •
2013
We describe procedures to quantify and characterize atherosclerotic lesions in mouse models using precision sectioning of the aortic sinus and ascending aorta combined with histochemical and immunohistochemical analysis.
09:22
Sectioning Mammary Gland Whole Mounts for Lesion Identification
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Cited by 13 •
2017
We developed a method to successfully remove, process, section, and stain, for histopathological evaluation, mammary tissue that had originally been fixed on slides as whole mounts. This method may promote the collection and evaluation of mammary gland whole mounts in reproductive and developmental test guideline studies.
08:16
Comparative Lesions Analysis Through a Targeted Sequencing Approach
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2019
This article describes a method to identify clonal and subclonal alterations among different specimens from a given patient. Although the experiments described here focus on a specific tumor type, the approach is broadly applicable to other solid tumors.
11:45
Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography
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Cited by 5 •
2015
Ex vivo analysis of arterial lesions from animal models of cardiovascular disease classically relies on histological and immunohistochemical techniques. These provide 2-dimensional measurements in 3-dimensional lesions. This manuscript describes the generation of arterial lesions for quantitative analysis in 3-dimensions using optical projection tomography.
FAQs
The lesion changes how patterned motor neuron activity is converted into force. Neural signals may still form part of an organized feeding program, but the damaged or absent muscle changes the mechanical output produced by that activity. Comparing movement before and after the manipulation therefore helps separate central motor commands from the peripheral forces that normally express them.
Force production determines the mechanical consequences of muscle activation during actions such as biting, swallowing, and egestion. Removing or damaging I7 changes that contribution without requiring researchers to treat the entire feeding system as functionally absent. Resulting movement differences can therefore reveal how one defined muscle supports coordinated behavior.
The preparation links activity in identified neurons and synapses with the actions those signals help generate. Because the peripheral muscle contribution is selectively disrupted, researchers can examine how central circuit activity relates to altered movement rather than observing neural activity in isolation. This provides a way to study how circuit output and muscle mechanics jointly shape behavior.
Intact and lesioned preparations provide contrasting mechanical conditions for the same broader feeding system. Differences in biting, swallowing, or egestion-related movements indicate which behavioral features depend on the I7 muscle contribution. The comparison also helps distinguish effects associated with altered force production from the organization of the underlying motor program.
The preparation begins by damaging or removing the defined I7 muscle, followed by examination of feeding-related movement in the altered preparation. Researchers can compare those observations with behavior or motor control in an intact preparation. This workflow focuses analysis on changes in force production and on the resulting mechanical expression of neural activity.
The lesion can be used to investigate coordinated feeding actions, including biting, swallowing, and egestion. These behaviors provide distinct contexts for asking how altered muscle mechanics affect motor output. Examining several actions broadens the analysis beyond a single movement and helps identify how the I7 contribution participates in the larger feeding repertoire.
Aplysia provides a preparation in which identified neurons and synapses can be related to observable behavior. Altering I7 adds a defined peripheral perturbation to that circuit-level analysis, allowing researchers to study how central motor control interacts with the muscles it commands. The approach supports mechanistic explanations that connect synaptic activity, motor patterns, force, and behavior.