Diabetes Diagnosis

Diabetes diagnosis is the clinical process of determining whether a person has diabetes by identifying persistent abnormalities in blood-glucose regulation, an essential step before treatment selection and monitoring. It typically combines laboratory measures such as fasting plasma glucose, oral glucose tolerance testing, random plasma glucose in symptomatic patients, and glycated hemoglobin (HbA1c), which reflects average glycemia over approximately two to three months. Results are interpreted with patient symptoms, repeat testing when needed, and the suspected diabetes type. In pharmacology, accurate diagnosis guides the choice and intensity of glucose-lowering therapy, supports assessment of treatment response, and helps reduce complications associated with prolonged hyperglycemia.

Diabetes Diagnosis - Related Videos

Education

JoVE Core - Pharmacology

Diabetes: Symptoms, Diagnosis, and Complications

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2024

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

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2026

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...

Research

JoVE Journal - Biology

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice

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Cited by 98 •

2007

Our protocol was developed to cleanly and easily deliver islets or cells under the kidney capsule of mice. Cells are concentrated into pellets in the final tubing used for transplanting the cells under the kidney capsule. The ease of this technique reduces stress to the cells and the mouse.

Research

JoVE Journal - Medicine
Free Sample

FISH for Pre-implantation Genetic Diagnosis

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Cited by 17 •

2011

This article describes the selection of suitable probes for single-cell FISH, spreading techniques for blastomere nuclei, and in situ hybridization and signal scoring, applied to pre-implantation genetic diagnosis (PGD) in a clinical setting.

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