Eugen Bleuler

Eugen Bleuler was a Swiss psychiatrist and psychologist whose work reshaped the psychological and medical understanding of schizophrenia and related psychotic disorders. In 1911, he introduced the term schizophrenia to replace Kraepelin’s dementia praecox, arguing that the condition reflected a disturbance in the association of ideas rather than an inevitably progressive decline. He organized its characteristic symptoms around four “As”: disturbances of affect, association, ambivalence, and autism, while distinguishing core symptoms from secondary features such as hallucinations and delusions. Bleuler’s framework influenced psychiatric classification, clinical description, and research on psychosis, although later diagnostic systems revised his terminology and some assumptions.

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Research

JoVE Journal - Chemistry

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

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Cited by 1 •

2022

The present protocol describes a detailed benchtop catalytic method that yields a unique borylated derivative of...

Selective Capture of 5-hydroxymethylcytosine from Genomic DNA

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Cited by 5 •

2012

Described is a two-step labeling process using β-glucosyltransferase (β-GT) to transfer an azide-glucose to 5-hmC, followed by click chemistry to transfer a biotin linker for easy and density-independent enrichment. This efficient and specific labeling method enables enrichment of 5-hmC with extremely low background and high-throughput epigenomic mapping via next-generation sequencing.

A Comprehensive Pipeline to Assess the Efficiency of Human Erythropoiesis In Vitro and Ex Vivo

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2025

Modeling erythropoiesis provides a valuable chance to comprehend the biological significance of actors in this process and to evaluate novel therapeutic approaches that may alleviate differentiation defects. Here, we describe a simple and reliable method to efficiently differentiate CD34+ hematopoietic stem and progenitor cells ex vivo.

High-Resolution Video Tracking of Locomotion in Adult Drosophila Melanogaster

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Cited by 26 •

2009

The study of complex locomotor behavior in Drosophila melanogaster is dependent upon the ability to quantify changes in a given fly's movement. This article demonstrates how to do this using a high-resolution tracking system.

An Acetyl-Click Chemistry Assay to Measure Histone Acetyltransferase 1 Acetylation

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2024

Quick and accurate chemical assays to screen for specific inhibitors are an important tool in the drug development arsenal. Here, we present a scalable acetyl-click chemistry assay to measure the inhibition of HAT1 acetylation activity.

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