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Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells
 

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells

Article DOI: 10.3791/50568-v 15:53 min August 21st, 2013
August 21st, 2013

Kapitel

Summary

The cytotoxic activity of the phenanthridine PJ-34 in cancer cells undergoing mitosis was documented in real time by live confocal imaging. PJ-34 eradicated human breast cancer MDA-MB-231 cells harboring extra-centrosomes in mitosis. Unlike normal bi-focal mitosis, the extra-centrosomes were not clustered in the two spindle poles in the presence of PJ-34.

Tags

Keywords: Cell Death Abnormal Mitosis Confocal Imaging Live Cancer Cells Phenanthrene Derivatives PARP1 Inhibitors Multi-centrosomal Cells Mitotic Failure Extra-centrosomes MDA-MB-231 Cells γ-tubulin Histone H2b PJ-34 PARP1 Deficient MEF
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