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Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
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JoVE Journal Chemie
Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)

DOI:
10.3791/51504-v

•

06:34 min

•

June 20, 2014

•

,
1Max-Planck-Institut fuer Kohlenforschung

Kapitel

  • 00:05Titel
  • 01:34Synthesis of Tetrahydrocarbazole Hydroperoxides
  • 02:45Coupling Reaction – Method A Using 10 mol% Trifluoroacetic Acid in Methanol
  • 04:03Coupling Reaction – Method B Using Acetic Acid
  • 04:52Results: Synthesis of Pharmaceutically Active Tetrahydrocarbazoles
  • 06:06Conclusion

Summary

Automatische Übersetzung

Automatische Übersetzung

A two-step procedure for the synthesis of pharmaceutically active indole-derivatives by C-H functionalization with anilines is described, using photo- and Brønsted acid catalysis.

Tags

C-H FunctionalizationPhotochemistryOxidationPeroxidesTetrahydrocarbazolesAntiviral CompoundsGreen Chemistry

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