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In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Article DOI: 10.3791/51537-v • 09:22 min • January 2nd, 2015
January 2nd, 2015 •
*1, *1, 1
1Department of Biochemistry and Molecular Biology, Michigan State University
* These authors contributed equally

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Summary
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Unmodified and hyperphosphorylated tau proteins were used in two in vitro aggregation assays to reveal the hyperphosphorylation-dependent fast aggregation kinetics. These assays pave the way for future screens for compounds that can modulate the propensity of hyperphosphorylated tau to form fibrils that underlie the progression of Alzheimer’s disease.

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In Vitro Aggregation Assays Hyperphosphorylated Tau Protein Alzheimer's Disease Tauopathies Neurofibrillary Tangles NFTs Cognitive Impairment Neurodegenerative Symptoms Tau Aggregation-based Therapeutics Recombinant Tau Synthetic Tau Phosphorylation Marks High-throughput Screens Hyperphosphorylated Tau Aggregates Novel Therapeutics
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