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Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry

Article DOI: 10.3791/55188-v • 10:54 min • February 4th, 2017
February 4th, 2017 •
*1, *1, 1, 1, 1
1Department of Chemistry and Chemical Biology, McMaster University
* These authors contributed equally

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Summary
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Here, we describe a protocol for radiolabeling and in vivo testing of tridentate 99mTc(I) chelate-tetrazine derivatives for pre-targeting and bioorthogonal chemistry.

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Technetium-99m Tetrazines Pre-targeting Bioorthogonal Chemistry Trans-cyclooctene Modified Biomolecules Radio Pharmaceuticals Radio-labeled Targeting Vectors Small Molecules Antibodies Radio Therapy Potassium Boranocabonate Sodium Carbonate Sodium Tetraborate Decahydrate Potassium Sodium Tartrate Tetrahydrate Technetium-99m Pertechnetate
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