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Murine Aortic Crush Injury
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Isolation of Intact Mitochondria from Skeletal Muscle by Differential Centrifugation for High-resolution Respirometry Measurements
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Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function

Article DOI: 10.3791/55201-v • 06:14 min • June 11th, 2017
June 11th, 2017 •
1,4, 2, 2,3,4, 2,3,4, 1,2,4
1Department of Surgery, Baltimore Veterans Affairs Medical Center, 2Department of Surgery, University of Maryland School of Medicine, 3Department of Physiology, University of Maryland School of Medicine, 4Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine

Kapitel

Summary
Automatic Translation

Restenosis following cardiovascular procedures (bypass surgery, angioplasty, or stenting) is a significant problem reducing the durability of these procedures. An ideal therapy would inhibit smooth muscle cell (VSMC) proliferation while promoting regeneration of the endothelium. We describe a model for simultaneous assessment of VSMC proliferation and endothelial function in vivo.

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Murine Aortic Crush Injury In Vivo Model Smooth Muscle Cell Proliferation Endothelial Function Restenosis Vascular Interventions Vascular Biology Reendothelialization Animal Model Key Questions Procedure Assessment Post Doctoral Fellow Laboratory Anesthetized C57BL/6 Mouse Ventral Abdomen Sternum Inguinal Region Disinfect Shoulder Area Analgesia Supine Position Surgical Tray Isothermal Pad Surgical Sight Betadine Chlorhexidine Alcohol Rinse Ointment Eyes Abdominal Laparotomy Incision
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