Eine familiäre Hypercholesterinämie menschlichen Leber chimärer Maus-Modell mit induzierten pluripotenten Stammzellen gewonnenen Hepatozyten

7.7K Aufrufe

Zitiert von 5

10:56 Min.

15. September 2018

10.3791/57556-v

15. September 2018

7.7K Aufrufe

Jiayin Yang^*¹^,²^,⁶ , Lai-Yung Wong^*² , Xiao-Yu Tian^*³ , Rui Wei¹^,² , Wing-Hon Lai² , Ka-Wing Au² , Zhiwei Luo⁴^,⁵ , Carl Ward⁴^,⁵ , Wai-In Ho² , David P. Ibañez⁴^,⁵ , Hao Liu⁴^,⁵ , Xichen Bao⁴^,⁵ , Baoming Qin⁴^,⁵ , Yu Huang³ , Miguel A. Esteban⁴^,⁵^,⁷ , Hung-Fat Tse¹^,²^,⁶^,⁷

¹Department of Medicine, University of Hong Kong-Shenzhen Hospital, ²The Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, ³School of Biomedical Sciences, Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, ⁴Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University, ⁵Laboratory of RNA, Chromatin, and Human Disease, CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, ⁶Research Centre of Heart, Brain, Hormone, and Healthy Ageing, Li Ka Shing Faculty of Medicine, University of Hong Kong, ⁷Hong Kong-Guangdong Stem Cell and Regenerative Medicine Research Centre, University of Hong Kong and Guangzhou Institutes of Biomedicine and Health

^* These authors contributed equally

Hier präsentieren wir ein Protokoll, um eine menschliche Leber chimärer Maus-Modell der Familiäre Hypercholesterinämie mit menschlichen induzierten pluripotenten Stammzellen gewonnenen Hepatozyten zu generieren. Dies ist ein wertvolles Modell zum Testen neuer Therapien für Hypercholesterinämie.