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Journal / Cancer Research / 用抗体阵列对信号转导通路的审问对酪氨酸激酶抑制剂的抗性评价…
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Cancer Research

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JoVE Journal Cancer Research
用抗体阵列对信号转导通路的审问对酪氨酸激酶抑制剂的抗性评价
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用抗体阵列对信号转导通路的审问对酪氨酸激酶抑制剂的抗性评价

Article DOI: 10.3791/57779-v • 07:42 min • September 19th, 2018
September 19th, 2018 •
1, 1, 1, 1, 1
1Lawrence J. Ellison Institute for Transformative Medicine, Center for Applied Molecular Medicine, University of Southern California

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在这里, 我们提出了抗体阵列的协议, 以确定各种细胞模型中信号通路的变化。这些变化, 由药物/缺氧/紫外线光/辐射, 或过度表达/下调/挖空, 是重要的各种疾病模型, 并可以表明治疗是否有效或能识别药物的机制电阻。

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癌症研究 问题 139 医学 药物治疗 抵抗 缺氧 过度表达 酪氨酸 信号转导 蛋白质组学 阵列 激酶 细胞信号 EGFR
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