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The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats

Article DOI: 10.3791/59050-v • 07:29 min • March 8th, 2019
March 8th, 2019 •
1, 1, 1, 1, 1, 1, 1, 1
1Cardiovascular Research Center, Department of Cardiology, Icahn School of Medicine at Mount Sinai

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Summary
Automatic Translation

The rodent left pneumonectomy is a valuable technique in pulmonary hypertension research. Here, we present a protocol to describe the rat pneumonectomy procedure and postoperative care to ensure minimal morbidity and mortality.

Tags

Left Pneumonectomy Monocrotaline Sugen Model Pulmonary Hypertension Rats Pulmonary Arterial Hypertension Plexiform Lesions Endothelial Damage Regenerative Medicine Congenital Heart Defects Post-pneumonectomy Patients Technique Anesthetizing Intubation Catheter Larynx Rat Ventilation Microscope Decubitus Position Heating Pad Forelimbs Tape Thorax
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