Testen von gezielten Krebstherapien mit struktureller DNA-Alterationsanalyse und patientenabgeleiteten Xenografts
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July 25, 2020
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Hier stellen wir ein Protokoll vor, um die Wirksamkeit gezielter Therapien zu testen, die auf der Grundlage der genomischen Zusammensetzung eines Tumors ausgewählt wurden. Das Protokoll beschreibt die Identifizierung und Validierung struktureller DNA-Umlagerungen, die Einplage von Patiententumoren in Mäuse und die Erprobung von Reaktionen auf entsprechende Medikamente.
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Cite this Article
Zhang, P., Kovtun, I. V. Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts. J. Vis. Exp. (161), e60646, doi:10.3791/60646 (2020).
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