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Immunology and Infection

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Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Article DOI: 10.3791/62135-v • 09:11 min • February 14th, 2021
February 14th, 2021 •
1, 2, 3,4, 1, 1, 1
1Department of Pathology, University of Michigan, 2Department of Surgery, Klinikum Rechts der Isar, Technische Universität München, 3Wallenberg Centre for Molecular Medicine, Linköping University, 4Department of Biomedical and Clinical Sciences (BKV), Linköping University

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Summary
Automatic Translation

Systematic scoring of intestinal inflammation using a free computer-assisted system is a powerful tool to quantitatively compare histopathological changes in colitis models characterized by the presence of ulcers and inflammatory changes. Histological colitis score evaluation strengthens clinical observations and facilitates data interpretation.

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Systematic Scoring Analysis Intestinal Inflammation Murine Dextran Sodium Sulfate-induced Colitis Model Mucosal Injury Histological Interpretation Quantitative Analysis Histological Data Disease Severity Genetic Backgrounds Tissue Preparation Euthanized Mouse Dissecting Pad Immobilize Forceps Scissors Incision Abdominal Skin Peritoneum Abdominal Cavity Midline Incision Pubic Bone Sides Of The Abdomen Tissues And Organs Large Intestine Pelvic Bone Visualized Organ Fat Removal
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