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JoVE Journal Medicine
Applicazioni tecniche di microelectrode array e patch clamp recordings su cardiomiociti derivati da cellule staminali pluripotenti indotte umane
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Applicazioni tecniche di microelectrode array e patch clamp recordings su cardiomiociti derivati da cellule staminali pluripotenti indotte umane

Article DOI: 10.3791/64265-v • 10:30 min • August 4th, 2022
August 4th, 2022 •
1,2, 1,2, 1,2, 1,2, 1,2,3
1Stanford Cardiovascular Institute, Stanford University School of Medicine, 2Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, 3Department of Radiology, Stanford University School of Medicine

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I cardiomiociti derivati da cellule staminali pluripotenti indotti dall'uomo (hiPSC-CM) sono emersi come un promettente modello in vitro per lo screening della cardiotossicità indotta da farmaci e la modellizzazione della malattia. Qui, dettagliamo un protocollo per misurare la contrattilità e l'elettrofisiologia delle hiPSC-CM.

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Medicina Numero 186
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