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Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Article DOI: 10.3791/64289-v • 07:11 min • September 28th, 2022
September 28th, 2022 •
*1, *1,2, *1, 3, 1,2, 1, 3, 1,2, 1,2
1Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, 2Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, 3Department of Radiation Oncology, the First Affiliated Hospital, Anhui Medical University
* These authors contributed equally

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Summary
Automatic Translation

This protocol presents the synthesis of cyclic peptides via bisalkylation between cysteine and methionine and the facile thiol-yne reaction triggered by the propargyl sulfonium center.

Tags

Cyclic Peptides On-tether Sulfonium Center Sulfonium Salt Fast Reaction Efficient Method Peptide Stabilization N-terminal Deprotection Solution Piperidine Morpholine DMF Vacuum Pump Dichloromethane N,N-dimethylformamide Resin Color Detection Coupling Of Peptides Polypropylene Tube N,N-diisopropylethylamine N,N'diisopropylcarbodiimide
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