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Bioengineering

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JoVE Journal Bioengineering
Terapia sonodinâmica no tratamento de glioblastoma multiforme em modelo de camundongo utilizando sistema portátil de ultrassom focalizado de bancada
Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management
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Terapia sonodinâmica no tratamento de glioblastoma multiforme em modelo de camundongo utilizando sistema portátil de ultrassom focalizado de bancada

Article DOI: 10.3791/65114-v • 09:07 min • February 10th, 2023
February 10th, 2023 •
1,2, 1,2, 3, 1,2, 4, 1, 1, 5, 1, 1,2,4,6,7
1Department of Neurosurgery, Johns Hopkins University School of Medicine, 2Department of Biomedical Engineering, Johns Hopkins University, 3Krieger School of Arts and Sciences, Johns Hopkins University, 4Department of Electrical Engineering and Computer Science, Johns Hopkins University, 5Department of Radiology, Cancer Imaging Division, Johns Hopkins University School of Medicine, 6Department of Mechanical Engineering, Johns Hopkins University, 7Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine

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Aqui, descrevemos um protocolo que detalha como realizar a terapia sonodinâmica em um modelo de glioblastoma in vivo de camundongo usando ultrassom focado guiado por ressonância magnética.

Tags

Terapia Sonodinâmica Glioblastoma Multiforme Modelo de Camundongo Sistema de Ultrassom Focado Agente Sonossensibilizante Sensibilidade Aumentada Tratamentos Clínicos Taxas de Sobrevida a Longo Prazo Tratamento Não Invasivo Tratamento Tumor-específico Sonosensibilizadores Espécies Oxidativas Reativas Apoptose Parâmetros Padronizados Estudos Pré-clínicos Otimização de Estratégia Terapêutica Modelo Pré-clínico de Roedores GBM FUS guiado por Ressonância Magnética (MRgFUS) Direcionamento Específico Tumor Cerebral Dispositivo de Bancada
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