Salvatore Piscuoglio Visceral Surgery and Precision Medicine Research Laboratory, Department of Biomedicine University of Basel Biography Publications Institution JoVE Articles Salvatore Piscuoglio has not added a biography. If you are Salvatore Piscuoglio and would like to personalize this page please email our Author Liaison for assistance. Publications Cell-Free DNA Genomic Profiling and Its Clinical Implementation in Advanced Prostate Cancer Cancers. Dec, 2023 | Pubmed ID: 38201475 Analysis of Off-tumour Toxicities of T-cell-engaging Bispecific Antibodies Via Donor-matched Intestinal Organoids and Tumouroids Nature Biomedical Engineering. Dec, 2023 | Pubmed ID: 38114742 Fragment-sequencing Unveils Local Tissue Microenvironments at Single-cell Resolution Nature Communications. Nov, 2023 | Pubmed ID: 38012149 High Density of CXCL12-positive Immune Cell Infiltration Predicts Chemosensitivity and Recurrence-free Survival in Ovarian Carcinoma Journal of Cancer Research and Clinical Oncology. Dec, 2023 | Pubmed ID: 37966614 Patient-derived Organoids Identify Tailored Therapeutic Options and Determinants of Plasticity in Sarcomatoid Urothelial Bladder Cancer NPJ Precision Oncology. Nov, 2023 | Pubmed ID: 37919480 Arginine Reprograms Metabolism in Liver Cancer Via RBM39 Cell. Nov, 2023 | Pubmed ID: 37804830 Colitis Is Associated with Loss of the Histidine Phosphatase LHPP and Upregulation of Histidine Phosphorylation in Intestinal Epithelial Cells Biomedicines. Aug, 2023 | Pubmed ID: 37626656 Early Age of Onset Is an Independent Predictor for a Worse Response to Neoadjuvant Therapies in Sporadic Rectal Cancer Patients Cancers. Jul, 2023 | Pubmed ID: 37509411 Cylindroma of the Breast with CYLD Gene Mutation: a Case Report and Review of the Literature Molecular Biology Reports. Aug, 2023 | Pubmed ID: 37389703 Minor Intron Splicing is Critical for Survival of Lethal Prostate Cancer Molecular Cell. Jun, 2023 | Pubmed ID: 37295433 PI3K Inhibition Circumvents Resistance to SHP2 Blockade in Metastatic Triple-negative Breast Cancer Journal of Mammary Gland Biology and Neoplasia. Jun, 2023 | Pubmed ID: 37294349 PipeIT2: A Tumor-only Somatic Variant Calling Workflow for Molecular Diagnostic Ion Torrent Sequencing Data Genomics. Mar, 2023 | Pubmed ID: 36796655 DNA Methylation Landscapes of Prostate Cancer Brain Metastasis Are Shaped by Early Driver Genetic Alterations Cancer Research. Apr, 2023 | Pubmed ID: 36749655 PI5P4Kα Supports Prostate Cancer Metabolism and Exposes a Survival Vulnerability During Androgen Receptor Inhibition Science Advances. Feb, 2023 | Pubmed ID: 36724278 Discovery of Synthetic Lethal Interactions from Large-scale Pan-cancer Perturbation Screens Nature Communications. Dec, 2022 | Pubmed ID: 36517508 The Prognostic Significance of CXCR4 and SDF-1 in Differentiated Thyroid Cancer Depends on CD8+ Density BMC Endocrine Disorders. Nov, 2022 | Pubmed ID: 36419107 Live Slow-frozen Human Tumor Tissues Viable for 2D, 3D, Ex Vivo Cultures and Single-cell RNAseq Communications Biology. Oct, 2022 | Pubmed ID: 36307545 Response by Du Fay De Lavallaz Et Al to Letter Regarding Article, "Skeletal Muscle Disorders: A Noncardiac Source of Cardiac Troponin T" Circulation. Oct, 2022 | Pubmed ID: 36214135 Transposon-activated POU5F1B Promotes Colorectal Cancer Growth and Metastasis Nature Communications. Aug, 2022 | Pubmed ID: 35987910 The Role of Chronic Liver Diseases in the Emergence and Recurrence of Hepatocellular Carcinoma: An Omics Perspective Frontiers in Medicine. 2022 | Pubmed ID: 35814741 The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples Cancers. Jun, 2022 | Pubmed ID: 35804847 Patient-derived Tumor Organoids for Personalized Medicine in a Patient with Rare Hepatocellular Carcinoma with Neuroendocrine Differentiation: a Case Report Communications Medicine. 2022 | Pubmed ID: 35789568 Author Correction: GATA3 and MDM2 Are Synthetic Lethal in Estrogen Receptor-positive Breast Cancers Communications Biology. Jul, 2022 | Pubmed ID: 35787660 Genomic Analysis of Focal Nodular Hyperplasia with Associated Hepatocellular Carcinoma Unveils Its Malignant Potential: a Case Report Communications Medicine. 2022 | Pubmed ID: 35603298 Integrative Proteogenomic Characterization of Hepatocellular Carcinoma Across Etiologies and Stages Nature Communications. May, 2022 | Pubmed ID: 35508466 Alterations in Homologous Recombination Repair Genes in Prostate Cancer Brain Metastases Nature Communications. May, 2022 | Pubmed ID: 35504881 GATA3 and MDM2 Are Synthetic Lethal in Estrogen Receptor-positive Breast Cancers Communications Biology. Apr, 2022 | Pubmed ID: 35440675 Skeletal Muscle Disorders: A Noncardiac Source of Cardiac Troponin T Circulation. Jun, 2022 | Pubmed ID: 35389756 Circulating Cell-Free DNA Captures the Intratumor Heterogeneity in Multinodular Hepatocellular Carcinoma JCO Precision Oncology. Mar, 2022 | Pubmed ID: 35263170 MiR-579-3p Controls Hepatocellular Carcinoma Formation by Regulating the Phosphoinositide 3-Kinase-Protein Kinase B Pathway in Chronically Inflamed Liver Hepatology Communications. Jun, 2022 | Pubmed ID: 35132819 Epigenetic Priming in Chronic Liver Disease Impacts the Transcriptional and Genetic Landscapes of Hepatocellular Carcinoma Molecular Oncology. Feb, 2022 | Pubmed ID: 34863035 Genomic Characterization of Small Cell Carcinomas of the Uterine Cervix Molecular Oncology. Feb, 2022 | Pubmed ID: 33830625 Standardizing Patient-Derived Organoid Generation Workflow to Avoid Microbial Contamination From Colorectal Cancer Tissues Frontiers in Oncology. 2021 | Pubmed ID: 35083141 High Density of CD16+ Tumor-Infiltrating Immune Cells in Recurrent Ovarian Cancer Is Associated with Enhanced Responsiveness to Chemotherapy and Prolonged Overall Survival Cancers. Nov, 2021 | Pubmed ID: 34830938 YAP/TAZ and ATF4 Drive Resistance to Sorafenib in Hepatocellular Carcinoma by Preventing Ferroptosis EMBO Molecular Medicine. Dec, 2021 | Pubmed ID: 34664408 Multi-omics Data Integration Reveals Novel Drug Targets in Hepatocellular Carcinoma BMC Genomics. Aug, 2021 | Pubmed ID: 34348664 MTOR Signaling Mediates ILC3-driven Immunopathology Mucosal Immunology. Nov, 2021 | Pubmed ID: 34341503 Systematic Identification of Novel Cancer Genes Through Analysis of Deep ShRNA Perturbation Screens Nucleic Acids Research. Sep, 2021 | Pubmed ID: 34313788 USP29-mediated HIF1α Stabilization is Associated with Sorafenib Resistance of Hepatocellular Carcinoma Cells by Upregulating Glycolysis Oncogenesis. Jul, 2021 | Pubmed ID: 34272356 ZNRF3 and RNF43 Cooperate to Safeguard Metabolic Liver Zonation and Hepatocyte Proliferation Cell Stem Cell. Oct, 2021 | Pubmed ID: 34129813 Mapping of MA and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-Low Induction of Therapy Resistance Molecular Cancer Research : MCR. Aug, 2021 | Pubmed ID: 34088870 Genomic Evolutionary Trajectory of Metastatic Squamous Cell Carcinoma of the Lung Translational Lung Cancer Research. Apr, 2021 | Pubmed ID: 34012793 Prostate Cancer Patient-derived Organoids: Detailed Outcome from a Prospective Cohort of 81 Clinical Specimens The Journal of Pathology. Aug, 2021 | Pubmed ID: 33934365 Non-viral Gene Delivery of the Oncotoxic Protein NS1 for Treatment of Hepatocellular Carcinoma Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2021 | Pubmed ID: 33894304 Transcriptional Enhancer Factor Domain Family Member 4 Exerts an Oncogenic Role in Hepatocellular Carcinoma by Hippo-Independent Regulation of Heat Shock Protein 70 Family Members Hepatology Communications. Apr, 2021 | Pubmed ID: 33860124 Adenylosuccinate Lyase is Oncogenic in Colorectal Cancer by Causing Mitochondrial Dysfunction and Independent Activation of NRF2 and MTOR-MYC-axis Theranostics. 2021 | Pubmed ID: 33754045 Nestin and CD34 Expression in Colorectal Cancer Predicts Improved Overall Survival Acta Oncologica (Stockholm, Sweden). Jun, 2021 | Pubmed ID: 33734917 Patient-derived Xenografts and Organoids Model Therapy Response in Prostate Cancer Nature Communications. Feb, 2021 | Pubmed ID: 33602919 Prognostic Significance of CD8+ T-cells Density in Stage III Colorectal Cancer Depends on SDF-1 Expression Scientific Reports. Jan, 2021 | Pubmed ID: 33436863 The Genetic Landscape of Metaplastic Breast Cancers and Uterine Carcinosarcomas Molecular Oncology. Apr, 2021 | Pubmed ID: 33021035 Role of Specialized Composition of SWI/SNF Complexes in Prostate Cancer Lineage Plasticity Nature Communications. Nov, 2020 | Pubmed ID: 33144576 Deciphering the Clonal Relationship Between Glandular and Squamous Components in Adenosquamous Carcinoma of the Lung Using Whole Exome Sequencing Lung Cancer (Amsterdam, Netherlands). Dec, 2020 | Pubmed ID: 33137577 Infiltration by IL22-Producing T Cells Promotes Neutrophil Recruitment and Predicts Favorable Clinical Outcome in Human Colorectal Cancer Cancer Immunology Research. Nov, 2020 | Pubmed ID: 32839156 Prevention of DsRNA-induced Interferon Signaling by AGO1x is Linked to Breast Cancer Cell Proliferation The EMBO Journal. Sep, 2020 | Pubmed ID: 32812257 High Expression of FAP in Colorectal Cancer Is Associated With Angiogenesis and Immunoregulation Processes Frontiers in Oncology. 2020 | Pubmed ID: 32733792 Identification of Somatic Mutations in Thirty-year-old Serum Cell-free DNA From Patients With Breast Cancer: A Feasibility Study Clinical Breast Cancer. Oct, 2020 | Pubmed ID: 32650988 Reliability of Liquid Biopsy Analysis: an Inter-laboratory Comparison of Circulating Tumor DNA Extraction and Sequencing with Different Platforms Laboratory Investigation; a Journal of Technical Methods and Pathology. Nov, 2020 | Pubmed ID: 32616816 A Pygopus 2-Histone Interaction Is Critical for Cancer Cell Dedifferentiation and Progression in Malignant Breast Cancer Cancer Research. Sep, 2020 | Pubmed ID: 32586983 Corrigendum to "HMGA1 Expression in Human Hepatocellular Carcinoma Correlates with Poor Prognosis and Promotes Tumor Growth and Migration in in Vitro Models" [Neoplasia 18 (2016) 724-731] Neoplasia (New York, N.Y.). Jul, 2020 | Pubmed ID: 32438307 Hormone Receptor and HER2 Assessment in Breast Carcinoma Metastatic to Bone: A Comparison Between FNA Cell Blocks and Decalcified Core Needle Biopsies Cancer Cytopathology. Feb, 2020 | Pubmed ID: 31883437 LATS1 but Not LATS2 Represses Autophagy by a Kinase-independent Scaffold Function Nature Communications. Dec, 2019 | Pubmed ID: 31848340 Preoperative Plasma Fatty Acid Metabolites Inform Risk of Prostate Cancer Progression and May Be Used for Personalized Patient Stratification BMC Cancer. Dec, 2019 | Pubmed ID: 31842810 Nectin-4 Expression Is an Independent Prognostic Biomarker and Associated With Better Survival in Triple-Negative Breast Cancer Frontiers in Medicine. 2019 | Pubmed ID: 31572728 Hepatocellular Carcinoma Xenografts Established From Needle Biopsies Preserve the Characteristics of the Originating Tumors Hepatology Communications. Jul, 2019 | Pubmed ID: 31334445 Author Correction: Genomic Characterization of Metastatic Breast Cancers Nature. Aug, 2019 | Pubmed ID: 31308536 Infiltration by Myeloperoxidase-positive Neutrophils is an Independent Prognostic Factor in Breast Cancer Breast Cancer Research and Treatment. Oct, 2019 | Pubmed ID: 31267330 PipeIT: A Singularity Container for Molecular Diagnostic Somatic Variant Calling on the Ion Torrent Next-Generation Sequencing Platform The Journal of Molecular Diagnostics : JMD. Sep, 2019 | Pubmed ID: 31229654 Genomic Characterization of Metastatic Breast Cancers Nature. May, 2019 | Pubmed ID: 31118521 Convergent Evolution of Copy Number Alterations in Multi-Centric Hepatocellular Carcinoma Scientific Reports. Mar, 2019 | Pubmed ID: 30872650 Therapeutic Targeting of CD146/MCAM Reduces Bone Metastasis in Prostate Cancer Molecular Cancer Research : MCR. May, 2019 | Pubmed ID: 30745464 Fibroepithelial Breast Lesion: When Sequencing Can Help to Make a Clinical Decision. A Case Report Clinical Breast Cancer. Feb, 2019 | Pubmed ID: 30470624 Lobular Carcinomas Display Intralesion Genetic Heterogeneity and Clonal Evolution in the Progression to Invasive Lobular Carcinoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2019 | Pubmed ID: 30185420 Reliability of Whole-Exome Sequencing for Assessing Intratumor Genetic Heterogeneity Cell Reports. Nov, 2018 | Pubmed ID: 30404001 Diagnostic Targeted Sequencing Panel for Hepatocellular Carcinoma Genomic Screening The Journal of Molecular Diagnostics : JMD. Nov, 2018 | Pubmed ID: 30142445 Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies Cell Reports. Jul, 2018 | Pubmed ID: 30067989 Genetic Heterogeneity and Actionable Mutations in HER2-positive Primary Breast Cancers and Their Brain Metastases Oncotarget. Apr, 2018 | Pubmed ID: 29755676 Cancer Diagnosis Using a Liquid Biopsy: Challenges and Expectations Diagnostics (Basel, Switzerland). May, 2018 | Pubmed ID: 29747380 Recurrent Hotspot Mutations in HRAS Q61 and PI3K-AKT Pathway Genes As Drivers of Breast Adenomyoepitheliomas Nature Communications. May, 2018 | Pubmed ID: 29739933 Circulating Cell-Free DNA in Hepatocellular Carcinoma: Current Insights and Outlook Frontiers in Medicine. 2018 | Pubmed ID: 29632864 The Protein Histidine Phosphatase LHPP is a Tumour Suppressor Nature. Mar, 2018 | Pubmed ID: 29562234 The Role of Long Non-Coding RNAs in Hepatocarcinogenesis International Journal of Molecular Sciences. Feb, 2018 | Pubmed ID: 29495592 Genomic Analysis Revealed New Oncogenic Signatures in -Mutant Hepatocellular Carcinoma Frontiers in Genetics. 2018 | Pubmed ID: 29456550 NGS-pipe: a Flexible, Easily Extendable and Highly Configurable Framework for NGS Analysis Bioinformatics (Oxford, England). Jan, 2018 | Pubmed ID: 28968639 Genomic and Transcriptomic Heterogeneity in Metaplastic Carcinomas of the Breast NPJ Breast Cancer. 2017 | Pubmed ID: 29214215 Phosphoprotein Enriched in Diabetes (PED/PEA15) Promotes Migration in Hepatocellular Carcinoma and Confers Resistance to Sorafenib Cell Death & Disease. Oct, 2017 | Pubmed ID: 29072691 Phyllodes Tumors with and Without Fibroadenoma-like Areas Display Distinct Genomic Features and May Evolve Through Distinct Pathways NPJ Breast Cancer. 2017 | Pubmed ID: 29043292 Diverse and Reversion Mutations in Circulating Cell-Free DNA of Therapy-Resistant Breast or Ovarian Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2017 | Pubmed ID: 28765325 Molecular Classification of Hepatocellular Carcinoma: The View from Metabolic Zonation Hepatology (Baltimore, Md.). Nov, 2017 | Pubmed ID: 28599064 High Mobility Group A1 Enhances Tumorigenicity of Human Cholangiocarcinoma and Confers Resistance to Therapy Molecular Carcinogenesis. Sep, 2017 | Pubmed ID: 28467612 HMGA1 Expression in Human Hepatocellular Carcinoma Correlates with Poor Prognosis and Promotes Tumor Growth and Migration in in Vitro Models Neoplasia (New York, N.Y.). Dec, 2016 | Pubmed ID: 27855356 HMGA1 Overexpression is Associated with a Particular Subset of Human Breast Carcinomas Journal of Clinical Pathology. Feb, 2016 | Pubmed ID: 26251519 High-resolution Breakpoint Analysis Provides Evidence for the Sequence-directed Nature of Genome Rearrangements in Hereditary Disorders Human Mutation. Feb, 2015 | Pubmed ID: 25418510 SH2D4A is Frequently Downregulated in Hepatocellular Carcinoma and Cirrhotic Nodules European Journal of Cancer (Oxford, England : 1990). Mar, 2014 | Pubmed ID: 24315626 3'-UTR Poly(T/U) Tract Deletions and Altered Expression of EWSR1 Are a Hallmark of Mismatch Repair-deficient Cancers Cancer Research. Jan, 2014 | Pubmed ID: 24158095 Long Noncoding RNA HOTTIP/HOXA13 Expression is Associated with Disease Progression and Predicts Outcome in Hepatocellular Carcinoma Patients Hepatology (Baltimore, Md.). Mar, 2014 | Pubmed ID: 24114970 HMGA1 and HMGA2 Protein Expression Correlates with Advanced Tumour Grade and Lymph Node Metastasis in Pancreatic Adenocarcinoma Histopathology. Feb, 2012 | Pubmed ID: 22276603 MAGE-A10 is a Nuclear Protein Frequently Expressed in High Percentages of Tumor Cells in Lung, Skin and Urothelial Malignancies International Journal of Cancer. Sep, 2011 | Pubmed ID: 21710496 TIA-1 Cytotoxic Granule-associated RNA Binding Protein Improves the Prognostic Performance of CD8 in Mismatch Repair-proficient Colorectal Cancer PloS One. 2010 | Pubmed ID: 21179245 A Hepatocellular Cancer Patient-derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth Fabian Haak*1, Gabriel Fridolin Hess*1, Philipp Sedlaczek1, Savas Deniz Soysal2, Jürg Vosbeck3, Salvatore Piscuoglio4,5, Mairene Coto-Llerena*4, Otto Kollmar*1 1Clarunis, Department of Visceral Surgery, University Center for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital Basel, 2Faculty of Medicine, University of Basel, 3Institute of Medical Genetics and Pathology, University Hospital Basel, 4Visceral Surgery and Precision Medicine Research Laboratory, Department of Biomedicine, University of Basel, 5IRCCS Humanitas Research Hospital JoVE 66245 Investigación sobre el cáncer
A Hepatocellular Cancer Patient-derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth Fabian Haak*1, Gabriel Fridolin Hess*1, Philipp Sedlaczek1, Savas Deniz Soysal2, Jürg Vosbeck3, Salvatore Piscuoglio4,5, Mairene Coto-Llerena*4, Otto Kollmar*1 1Clarunis, Department of Visceral Surgery, University Center for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital Basel, 2Faculty of Medicine, University of Basel, 3Institute of Medical Genetics and Pathology, University Hospital Basel, 4Visceral Surgery and Precision Medicine Research Laboratory, Department of Biomedicine, University of Basel, 5IRCCS Humanitas Research Hospital JoVE 66245 Investigación sobre el cáncer