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Differentiating Human Pluripotent Stem Cells into Pancreatic β-Cells

February 2nd, 2024
1, 2, 2, 1,3, 1,4,5
1Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Cell Biology and Functional Genomics, 2Departments of Pediatrics, Naomi Berrie Diabetes Center, Obstetrics and Gynecology, Columbia Stem Cell Initiative, Columbia University Irving Medical Center, Columbia University, 3Department of Diabetes, Imperial College Healthcare NHS Trust, 4Faculté de Médicine, Université de Montréal, 5Lee Kong Chian Imperial Medical School, Nanyang Technological University

Summary
Automatic Translation

本文介绍了一种用于β细胞样细胞定向分化和功能分析的方案。我们描述了在产生产生胰岛素的胰腺细胞之前，人类多能干细胞的最佳培养条件和传代。六阶段分化从明确的内胚层形成发展到功能性β细胞样细胞，响应葡萄糖分泌胰岛素。

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