Tokai University School of Medicine 1 article published in JoVE Medicine Murine Model of Central Venous Stenosis using Aortocaval Fistula with an Outflow Stenosis Toshihiko Isaji1,2,3, Shun Ono1,2,4,5, Takuya Hashimoto1,2,3, Kota Yamamoto1,2,3, Ryosuke Taniguchi1,2,3, Haidi Hu1,2, Tun Wang1,2, Jun Koizumi4, Toshiya Nishibe5, Katsuyuki Hoshina3, Alan Dardik1,2,6 1Department of Surgery, Yale University, 2Vascular Biology and Therapeutics Program, Yale University, 3Department of Vascular Surgery, University of Tokyo, 4Department of Diagnostic Radiology, Tokai University School of Medicine, 5Department of Cardiovascular Surgery, Tokyo Medical University, 6Department of Vascular Surgery, VA Connecticut Healthcare Systems An aortocaval fistula was created by puncturing the murine infra-renal aorta through both walls into the inferior vena cava and was followed by creation of a stenosis in its outflow via partial ligation of the inferior vena cava. This reproducible model can be used to study central venous stenosis.