Diazotizing Primary Amines with Nitrous Acid

Diazotizing primary amines with nitrous acid forms diazonium salts. The reaction begins with nitrous acid, a weak and unstable acid made in situ from sodium nitrite and cold, dilute hydrochloric acid. In acidic solution, nitrous acid is protonated and loses water to form the nitrosonium ion, which acts as the electrophile.

Durante una reacción de diazotización, las aminas primarias reaccionan con los iones de nitrosonio, generados in situ a través de agentes nitrosantes, para producir sales de diazonio a través de una serie de pasos.

El mecanismo comienza con un ataque nucleofílico de la amina 1° sobre el ion nitrosonio electrofílico para formar un...