Routes to Amines from Oximes and Nitro Groups

Oximes and nitro compounds can both be converted into primary amines. Oximes are reduced by catalytic hydrogenation, hydride reduction, or sodium metal reduction. A primary amine is an amine with one carbon group attached to nitrogen, so this step is an important way to build nitrogen-containing molecules.

Carbonyl compounds and hydroxylamines react to give oximes.

Oximes can be reduced to primary amines via hydrogenation, hydride reduction, or reduction using sodium metal.

Aromatic amines, like aniline, can be prepared by reducing nitroaromatics using catalytic hydrogenation or acidic reduction by active metal.

Catalytic hydr...