Continuous Extraction
Continuous Extraction - Related Videos
04:52
Dynamic Continuous Blood Extraction from Rat Heart via Noninvasive Microdialysis Technique
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Cited by 1 •
2022
The present protocol describes a simple and efficient method for the real-time and dynamic collection of rat heart blood using the microdialysis technique.
02:55
Extraction - Concepts
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2020
Extraction Extraction is a common technique used in organic chemistry to isolate a target compound. In the extraction process, a solute is transferred from one phase to another to separate it from unreacted starting materials or impurities. Extraction is also used to facilitate the isolation of a solute from a reaction solvent that is difficult to remove by evaporation, such as a solvent with a high boiling point. Generally, there are three types of extractions. First, in solid-liquid...
19:00
Extraction - Student Protocol
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2020
Source: Lara Al Hariri and Ahmed Basabrain at the University of Massachusetts Amherst, MA, USA Cellulose RecoveryExpand Extraction and filtration can separate compounds based on their solubility properties. In this lab, you'll separate a mixture of cellulose, caffeine, and benzoic acid based on their solubilities in dichloromethane, or DCM, and water. Caffeine and benzoic acid are both soluble in DCM, but cellulose is not. Thus, in this part, you'll first dissolve as much of the mixture as...
09:40
Batch and Continuous Bioreactors
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2023
Bioreactors are used to grow organisms in large volumes, thereby enabling the production of mass quantities of the target product. These reactors can be batch reactors, which contain all of the components needed for cell growth, or continuous reactors, which have inlet and outlet ports allowing for the addition of fresh growth media and the removal of cell waste. This video presents batch and continuous reactors and demonstrates the use of bioreactors to grow bacteria in the laboratory.
06:42
Extraction of Biomarkers from Sediments - Accelerated Solvent Extraction
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2023
Source: Laboratory of Jeff Salacup - University of Massachusetts Amherst The distribution of a group of organic biomarkers called glycerol-dialkyl glycerol-tetraethers (GDGTs), produced by a suite of archaea and bacteria, were found in modern sediments to change in a predictable manner in response to air or water temperature1,2. Therefore, the distribution of these biomarkers in a sequence of sediments of known age can be used to reconstruct the evolution of air and/or water temperature on...
FAQs
Recovery depends on how strongly the target compound favors the selective phase compared with the biological feed. Solubility differences can move compounds into the solvent, partitioning describes their distribution between phases, and binding can retain a target in the receiving phase. These mechanisms determine which metabolites, proteins, lipids, or other bioproducts transfer effectively.
Controlled flow rates, mixing, and phase separation are central operating factors. Flow determines how long the phases contact one another, while mixing promotes interaction across their interface. Separation must then distinguish the phases reliably so the extracted material can leave the system. Together, these conditions sustain transfer and support consistent recovery during ongoing operation.
The interface is where the target compound moves from the biological feed into the selective phase. Effective contact increases the opportunity for solubility, partitioning, or binding differences to drive transfer, whereas inadequate contact can limit recovery. Subsequent phase separation preserves the transferred product and allows fresh feed and selective phase to continue entering the process.
Continuous extraction reduces the interruptions associated with repeatedly stopping, processing, and restarting separate batches. Feed materials and extracted products move through the system as operation proceeds, which can support steadier processing conditions. In bioengineering, this continuity also creates opportunities to connect extraction with cultivation or downstream purification rather than treating each stage as an isolated batch.
A typical workflow introduces the biological feed and a selective solvent or other phase, establishes controlled flow, and promotes contact through mixing. The phases then separate so the extracted stream can be collected while feed materials and additional selective phase continue moving through the system. The same sequence can operate during cultivation or after cultivation, depending on the process design.
Bioengineers can apply the technique during cultivation when product recovery is integrated with the bioreactor, or after cultivation as part of downstream processing. Its use is relevant when recovering metabolites, proteins, lipids, or other valuable bioproducts from a biological feed. The timing depends on whether extraction should accompany production or follow the completed cultivation stage.
By reducing batch interruptions and enabling integration with bioreactors or downstream purification, the approach can support higher productivity, improved process consistency, and scalability. Its value is not limited to one product class: the same operating concept can be applied to metabolites, proteins, lipids, and other valuable bioproducts when their transfer into a selective phase is feasible.