Medical Device Coatings
Medical Device Coatings - Related Videos
06:34
Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices
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2024
Here, we present a protocol for derivatizing medical devices with protein therapeutics by conjugating protein therapeutics to a polyvinyl alcohol membrane casted on medical devices. Conjugation of protein-based therapeutics allows for localized and concentrated delivery and is a cost-effective approach that requires vastly lower drug amounts for dosing while minimizing off-target effects.
10:43
High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
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Cited by 2 •
2016
A high-throughput microarray method for the identification of polymers which reduce bacterial surface binding on medical devices is described.
10:43
Rapid and Low-cost Prototyping of Medical Devices Using 3D Printed Molds for Liquid Injection Molding
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Cited by 34 •
2014
We have devised a method for low-cost and rapid prototyping of liquid elastomer rubber injection molded devices by using fused deposition modeling 3D printers for mold design and a modified desiccator as a liquid injection system.
06:10
A 3D-Printed Silicone-Coated Device to Model Catheter-Associated Urinary Tract Infection
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2025
Source:Ocean E. Clarke1, Romy A. Dop1, Tom Hasell1, Joanne L. Fothergill1, Daniel R. Neill21University of Liverpool, 2 University of DundeeThis video demonstrates the use of a 3D-printed, silicone-coated device that mimics the inner surface of urinary catheters to simulate catheter-associated urinary tract infection.
06:59
A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
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Cited by 5 •
2016
This study presents a novel device that offers an easy route to quickly provide medications and fluids in patients with limited or difficult IV access. This small-diameter device is placed in the distal third of the rectum, allowing for ongoing medication and fluids administration.
FAQs
They modify surface chemistry, wettability, roughness, or electrical charge, which changes how surrounding biological materials contact the device. These adjustments can influence compatibility with blood, tissue attachment, friction, and microbial adhesion without requiring a different underlying device material. In bioengineering, selecting the relevant surface property helps align device performance with its intended physiological environment.
Bioactive compounds add a functional component beyond passive surface modification. When incorporated into a coating, they can be released under defined conditions to produce a localized effect at the device interface. This approach supports site-specific drug delivery and may help address biological complications associated with implantation while limiting the need for activity throughout the body.
The important property depends on the biological problem the device must address. Wettability, roughness, charge, and surface chemistry can each alter interactions with blood, tissue, microbes, or surrounding fluids. A coating intended to support tissue integration may therefore require a different surface design from one intended to reduce bacterial adhesion or friction.
Selection begins with the device function and the surrounding biological conditions. Stents, catheters, sensors, and orthopedic implants may require different combinations of friction control, tissue integration, microbial resistance, biocompatibility, or localized delivery. Researchers match the coating’s surface characteristics and any incorporated bioactive compound to the interaction that most strongly affects safety and performance.
A practical workflow identifies the unwanted device interaction, chooses the surface feature or bioactive function that addresses it, and then considers how that design will behave during use. Researchers evaluate whether the coating supports the desired blood or tissue response, limits microbes or friction, and maintains performance over the device’s service life.
Applications include stents, catheters, sensors, and orthopedic implants, with the coating tailored to each device’s biological interface. Research may focus on improving biocompatibility, supporting tissue integration, reducing friction, limiting bacterial adhesion, or delivering compounds locally. These uses connect materials science with cellular and molecular biology to improve device safety and function.