Physiological Shear Rate
Physiological Shear Rate - Related Videos
09:20
The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress
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Cited by 10 •
2016
Different levels and patterns of fluid shear are known to modulate endothelial gene expression, phenotype and susceptibility to disease. We discuss the assembly and use of 'shear rings': a model that produces unidirectional, periodic shear stress patterns. Shear rings are simple to assemble, economical and can produce high cell yields.
06:58
Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat
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Cited by 10 •
2015
The purpose of this protocol is to demonstrate the principles and techniques for measuring and calculating glomerular filtration rate, urine flow rate, and excretion of sodium and potassium in a rat. This demonstration can be used to provide students with an overall conceptual understanding of how to measure renal function.
09:52
Generation of Shear Adhesion Map Using SynVivo Synthetic Microvascular Networks
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Cited by 10 •
2014
Flow chambers used in adhesion experiments typically consist of linear flow paths and require multiple experiments at different flow rates to generate a shear adhesion map. SynVivo-SMN enables the generation of shear adhesion map using a single experiment utilizing microliter volumes resulting in significant savings in time and consumables.
05:33
Physiology of the Circulatory System - Concepts
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2019
Homeostasis Conditions in the external environment of an organism can change rapidly and drastically. To survive, organisms must maintain a fairly constant internal environment, which involves continuous regulation of temperature, pH, and other factors. This balanced state is known as homeostasis, which describes the processes by which organisms maintain their optimal internal conditions. To maintain homeostasis, organisms have developed structures with distinct functions. Physiology is the...
04:53
A Novel Capsulorhexis Technique Using Shearing Forces with Cystotome
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Cited by 5 •
2010
This video demonstrates a novel capsulorhexis technique in modern cataract surgery. Capsulorhexis is the most difficult and important part of phacoemulsification surgery.
FAQs
The velocity gradient determines how fluid motion varies from the vessel center toward the wall, where endothelial cells experience the local mechanical environment. This spatial difference is essential for designing models that reproduce conditions near the vessel lining rather than treating flow as uniform. Such control helps bioengineers examine endothelial responses under more physiologically relevant conditions.
Endothelial cells detect flow-related mechanical forces through mechanotransduction pathways, which convert physical stimulation into cellular signaling. Applying controlled shear rates therefore allows researchers to investigate how the vessel lining senses its environment and changes its function. This mechanistic perspective supports studies of endothelial behavior in engineered vascular models and cell culture platforms.
Controlled physiological shear rates increase the relevance of experiments by reproducing aspects of fluid motion found in living tissues. In contrast, conditions that do not reflect tissue flow may provide less representative information about endothelial function, blood compatibility, or biomaterial performance. Bioengineers can use this comparison to determine whether an engineered system behaves appropriately under flow.
Researchers establish controlled flow conditions in microfluidic systems, vascular models, or cell culture platforms, then expose cells or biomaterials to those conditions. The experimental design should represent the intended tissue environment closely enough to evaluate responses to flow. This approach creates a reproducible setting for examining endothelial function, compatibility with blood, tissue development, or material behavior.
Physiological shear rate testing is useful when a biomaterial may contact flowing blood or interact with vascular tissue. Exposing the material to controlled flow helps researchers assess blood compatibility and performance under conditions that better resemble its intended biological environment. The resulting information can guide evaluation of whether the material remains suitable in a vascular application.
Flow-based models can provide information about endothelial function, tissue development, blood compatibility, and biomaterial performance. Because the systems reproduce controlled mechanical conditions, researchers can relate observed cellular or material behavior to the applied shear environment. These outcomes support the development of more physiologically relevant engineered models and therapeutic testing platforms.