Particle Self-assembly

Particle self-assembly is the spontaneous organization of particles into ordered or structured arrangements through local interactions rather than direct external assembly, making it a foundation for designing materials across chemistry and nanoscience. The process is governed by forces such as electrostatic attraction, hydrogen bonding, hydrophobic effects, and van der Waals interactions, while Brownian motion and conditions including concentration, solvent composition, temperature, and pH influence whether particles form stable clusters, sheets, or three-dimensional networks. By controlling these variables, researchers can tune particle spacing, structure, and organization to produce functional colloids, photonic materials, catalysts, and responsive nanosystems, linking molecular interactions to macroscopic properties.

Particle Self-assembly - Related Videos

Research

JoVE Journal - Chemistry
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Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

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Cited by 25 •

2013

We describe experimental details of the synthesis of patterned and reconfigurable particles from two dimensional (2D) precursors. This methodology can be used to create particles in a variety of shapes including polyhedra and grasping devices at length scales ranging from the micro to centimeter scale.

Research

JoVE Journal - Chemistry

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

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Cited by 17 •

2016

We report on a smart application of carbon nanotubes for kinetic stabilization of lipid particles that contain self-assembled nanostructures in their cores. The preparation of lipid particles requires rather low concentrations of carbon nanotubes permitting their use in biomedical applications such as drug delivery.

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles

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Cited by 1 •

2016

We propose a simple self-assembly technique of silica colloidal nanoparticles to create a nanofluidic junction between two microchannels in polydimethylsiloxane (PDMS). Using this technique, a nanoporous bead membrane with a pore size down to ~45 nm was built inside a microchannel and applied to electrokinetic preconcentration of DNA samples.

Assembly of Porous Monolithic Materials Using a Pickering Emulsion Strategy Stabilized by Metal–Organic Framework (MOF) Particles

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2026

This study successfully uses MIL-96(Al) Metal-Organic Frameworks particles to stabilize Pickering emulsions, which serve as templates to form mechanically robust, hierarchically porous monolithic materials. This method allows scalable MOF shaping while preserving crystal integrity. Tuning formulation is key to controlling pore size, interconnectivity, permeability, and robustness.

Education

JoVE Core - Molecular Biology

Protein Complex Assembly

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2020

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types. Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes. Many viruses self-assemble into a fully functional unit using the infected host cell to...

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