Functional Lung Mri
Functional Lung Mri - Related Videos
06:06
Optogenetic Functional MRI
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Cited by 15 •
2016
This protocol describes the steps and data analysis required to successfully perform optogenetic functional magnetic resonance imaging (ofMRI). ofMRI is a novel technique that combines high-field fMRI readout with optogenetic stimulation, allowing for cell type-specific mapping of functional neural circuits and their dynamics across the whole living brain.
05:56
Phase-Resolved Functional Lung MRI for Pulmonary Ventilation and Perfusion (V/Q) Assessment
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Cited by 8 •
2024
Here, we describe the implementation of phase-resolved functional lung MRI as a contrast-agent-free proton MR technique for the assessment of pulmonary ventilation and perfusion dynamics. Validated and applicable across different field strengths and age groups, it could enhance clinical decision-making in the future by aiding in disease quantification and therapy monitoring.
02:09
Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
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Cited by 2 •
2024
CT and 129Xe MRI provide complementary lung structure-function information that can be exploited for regional analysis using image registration. Here, we provide a protocol that builds from the existing literature for 129Xe MR to CT image registration using open-source platforms.
08:36
Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI
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Cited by 4 •
2012
A technique is described for broadly opening the blood-brain barrier in the mouse using microbubbles and ultrasound. Using this technique, manganese can be administered to the mouse brain. Because manganese is an MRI contrast agent that accumulates in depolarized neurons, this approach enables imaging of neuronal activity.
13:04
Measuring the Subjective Value of Risky and Ambiguous Options using Experimental Economics and Functional MRI Methods
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Cited by 19 •
2012
Using functional MRI and behavioral methods to determine the neural representation of the subjective value of risky and ambiguous options in the human brain.
FAQs
The technique emphasizes regional function rather than anatomy alone. Its measurements can show whether inhaled gas reaches lung regions evenly, whether oxygen transfer is impaired, and whether pulmonary blood flow is altered. This functional information may identify abnormalities that are not adequately characterized by structural images, helping investigators assess the physiological distribution and severity of pulmonary disease.
Inhaled hyperpolarized helium-3 or xenon-129 produces an MRI signal that can be detected as the gas distributes through the lungs. The resulting maps show regional ventilation, making differences in gas delivery visible across lung areas. This approach is particularly useful for examining uneven ventilation in diseases such as asthma, chronic obstructive pulmonary disease, and cystic fibrosis.
Oxygen-enhanced MRI detects changes in tissue relaxation as oxygen moves through the lungs. Those relaxation changes provide an indirect functional readout of oxygen movement and can reveal impaired gas exchange. Unlike methods that primarily map inhaled tracer-gas distribution, this approach focuses on how oxygen affects the measured MRI signal as it passes into pulmonary tissues.
Regional ventilation defects, impaired gas transfer, and altered pulmonary blood flow are among the abnormalities that these measurements can reveal. Their regional nature helps distinguish uneven lung involvement rather than relying only on a whole-lung summary. Such findings are relevant to evaluating pulmonary dysfunction in asthma, chronic obstructive pulmonary disease, and cystic fibrosis.
The method selected determines the inhaled substance and the functional signal being measured. Some examinations use hyperpolarized helium-3 or xenon-129 to map gas distribution, whereas oxygen-enhanced MRI measures relaxation changes associated with oxygen movement. In every case, MRI supplies the imaging framework, while the chosen gas or oxygen-sensitive response determines the functional information obtained.
Because MRI uses no ionizing radiation, functional measurements can support repeated assessment of pulmonary disease without adding radiation exposure from the imaging method itself. This characteristic is valuable when researchers need to examine disease progression or treatment response over time. Repeated studies can compare regional ventilation, gas transfer, or blood-flow findings across different assessments.