Hindlimb Motility

Hindlimb motility is the coordinated movement of the rear limbs, produced by interactions among the brain, spinal cord, peripheral nerves, muscles, joints, and sensory systems. It depends on motor signals traveling through spinal circuits to activate patterned muscle contractions, while sensory feedback adjusts balance, force, and timing during posture and locomotion. In medicine, evaluating hindlimb motility helps characterize motor development, neurological injury, neuromuscular disorders, and recovery after treatment. Measurements of movement, strength, coordination, and gait can provide functional outcomes in animal models and clinical research, linking tissue-level changes to broader effects on mobility and independence.

Hindlimb Motility - Related Videos

Research

JoVE Journal - Medicine

Methods for Acute and Subacute Murine Hindlimb Ischemia

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Cited by 31 •

2016

Surgical induction of hindlimb ischemia in the mouse is useful to examine angiogenesis, however this is compromised in certain inbred mouse strains that display marked ischemia-induced tissue necrosis. Methods are described to induce subacute limb ischemia using ameroid constrictors to circumvent this problem through the induction of gradual arterial occlusion.

Research

JoVE Journal - Biology
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Gastrointestinal Motility Monitor (GIMM)

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Cited by 36 •

2010

Evaluation of colonic motility in the guinea pig distal colon with the Gastrointestinal Motility Monitor (GIMM) is a straightforward and simple to learn approach to quantitatively evaluate propulsive motility in the gastrointestinal tract.

Education

JoVE Science Education - Advanced Biology

An Introduction to Cell Motility and Migration

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2023

Cell motility and migration play important roles in both normal biology and in disease. On one hand, migration allows cells to generate complex tissues and organs during development, but on the other hand, the same mechanisms are used by tumor cells to move and spread in a process known as cancer metastasis. One of the primary cellular machineries that make cell movement possible is an intracellular network of myosin and actin molecules, together known as “actomyosin”, which creates a...

Research

JoVE Journal - Biology
Free Sample

Spatiotemporal Mapping of Motility in Ex Vivo Preparations of the Intestines

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Cited by 26 •

2016

Recently available video recording and spatiotemporal mapping (STmap) techniques make it possible to visualize and quantify both propagating and mixing patterns of intestinal motility. The goal of this protocol is to explain the generation and analysis of STmaps using the GastroIntestinal Motility Monitoring (GIMM) system.

High-throughput Method for Observing Motility Phenotypes in Pseudomonas aeruginosa

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2025

This protocol presents a rapid and efficient method for identifying genetic factors involved in various types of motilities in Pseudomonas aeruginosa.

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