Hormone Deprivation
Hormone Deprivation - Related Videos
02:13
Types of Hormones
0 Views •
2019
Hormones can be classified into three main types based on their chemical structures: steroids, peptides, and amines. Their actions are mediated by the specific receptors they bind to on target cells. Steroid hormones are derived from cholesterol and are lipophilic in nature. This allows them to readily traverse the lipid-rich cell membrane to bind to their intracellular receptors in the cytoplasm or nucleus. Once bound, the cytoplasmic hormone-receptor complex translocates to the nucleus.
01:33
Hormonal Regulation
0 Views •
2019
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
01:56
Plant Hormones
0 Views •
2020
Plant hormones—or phytohormones—are chemical molecules that modulate one or more physiological processes of a plant. In animals, hormones are often produced in specific glands and circulated via the circulatory system. However, plants lack hormone-producing glands. Instead, plant hormones are often produced in regions of active growth, like the tips of roots and shoots. Additionally, even very low concentrations of plant hormones can have a profound effect on growth and development processes.
11:01
Monitoring Plant Hormones During Stress Responses
0 Views •
Cited by 11 •
2009
A simple method is provided that allows for the rapid extraction and analysis of multiple plant hormones from small tissue samples. The procedure uses vapor phase extraction as the solemn purification step. Samples are analyzed by GC/MS with chemical ionization that produces mainly (M+1)+ ions.
02:33
Assessing Atmospheric Pressure Plasma Treatment in Glucose-Deprived Neuroblastoma Cells
0 Views •
2025
Source: Yan, X., et. al., New Application of an Atmospheric Pressure Plasma Jet as a Neuro-protective Agent Against Glucose Deprivation-induced Injury of SH-SY5Y Cells. J. Vis. Exp. (2017)The video demonstrates the neuroprotective activity of low-dose atmospheric pressure plasma treatment in glucose-deprived neuroblastoma cells by modulating oxidative stress and enhancing cell viability.
FAQs
The intervention can act at several stages of hormone action: it may reduce hormone production, block access to target receptors, or interrupt signaling through the hypothalamic-pituitary-gonadal axis. These mechanisms lower either the amount of circulating hormone or the tissue’s ability to respond to it. Selecting the point of intervention helps align treatment with the disease process being managed.
This axis coordinates hormonal signaling between the hypothalamus, pituitary gland, and gonads. Interrupting it can reduce downstream hormone production and thereby diminish signaling that supports certain disease processes. Its importance is clinical because changes across the axis can influence more than one body system, requiring attention to effects on fertility, bone health, metabolism, and cardiovascular health.
Reducing production lowers the available hormone, whereas receptor blockade prevents the hormone from producing its effect at responsive tissues. Both strategies can weaken hormone-driven signaling, but they intervene at different stages of the pathway. This distinction helps explain why hormone deprivation may be achieved through different targeted approaches rather than through a single universal treatment.
In hormone-responsive prostate and breast cancers, reducing androgen or estrogen signaling can slow tumor growth. Treatment may lower the relevant hormone, prevent receptor activation, or interrupt upstream signaling. The therapeutic goal is not simply to change hormone levels, but to reduce the biological stimulus that supports tumor progression in cancers dependent on those hormonal pathways.
Medication, surgery, and other targeted interventions may be used to suppress hormone production or block hormonal effects. The appropriate approach depends on the disease process, the hormone pathway involved, and the patient’s clinical situation. Because these options act differently, treatment planning must connect the chosen intervention with the intended endocrine effect and its expected consequences.
Monitoring should account for the broader effects of systemic hormone changes, including possible consequences for bone, metabolism, fertility, and cardiovascular health. Clinicians use this information to select therapy carefully and manage adverse effects as treatment continues. Such follow-up is important because controlling disease-related hormone signaling may also alter normal endocrine functions throughout the body.