Leaflet Grasping
Leaflet Grasping - Related Videos
11:12
Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves
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Cited by 5 •
2013
There has been renewed interest in developing polymer valves. Here, the objectives are to demonstrate the feasibility of modifying a commercial pulse duplicator to accommodate tri-leaflet geometries and to define a protocol to present polymer valve hydrodynamic data in comparison to native and prosthetic valve data collected under near-identical conditions.
09:41
Estimation of Contact Regions Between Hands and Objects During Human Multi-Digit Grasping
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Cited by 9 •
2023
When we grasp an object, multiple regions of the fingers and hand typically make contact with the object's surface. Reconstructing such contact regions is challenging. Here, we present a method for approximately estimating the contact regions by combining marker-based motion capture with existing deep learning-based hand mesh reconstruction.
10:51
Frame-by-Frame Video Analysis of Idiosyncratic Reach-to-Grasp Movements in Humans
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Cited by 7 •
2018
This protocol describes how to use frame-by-frame video analysis to quantify idiosyncratic reach-to-grasp movements in humans. A comparative analysis of reaching in sighted versus unsighted healthy adults is used to demonstrate the technique, but the method can also be applied to the study of developmental and clinical populations.
10:29
Combining 3D-Printing and Electrospinning to Manufacture Biomimetic Heart Valve Leaflets
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Cited by 6 •
2022
The presented method offers an innovative way for engineering biomimetic fiber structures in three-dimensional (3D) scaffolds (e.g., heart valve leaflets). 3D-printed, conductive geometries were used to determine shape and dimensions. Fiber orientation and characteristics were individually adjustable for each layer. Multiple samples could be manufactured in one setup.
07:34
Layer Microdissection of Tricuspid Valve Leaflets for Biaxial Mechanical Characterization and Microstructural Quantification
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2022
This protocol describes the biaxial mechanical characterization, polarized spatial frequency domain imaging-based collagen quantification, and microdissection of tricuspid valve leaflets. The provided method elucidates how the leaflet layers contribute to the holistic leaflet behaviors.
FAQs
The device brings opposing leaflet edges together so they meet more effectively during valve closure. This improved coaptation, meaning closer contact between the leaflet surfaces, narrows the opening through which blood can flow backward. By reducing the pathway for regurgitation, the intervention can improve valve function while preserving the goal of catheter-based treatment.
Grasping must secure enough leaflet tissue to create a stable repair, but excessive or poorly positioned capture can interfere with normal leaflet movement. The operator therefore aims for stable tissue capture that supports edge joining without impairing valve motion. This balance directly affects whether the repair reduces regurgitation while maintaining functional valve opening and closure.
Imaging guides the device as it approaches the valve, aligns with the target leaflets, advances beneath them, and confirms tissue capture. Because the technique depends on precise positioning, imaging helps the operator control each stage and assess whether the leaflets have been secured appropriately. It is therefore central to achieving a stable repair rather than simply advancing the device.
Controlled manipulation allows the device to approach and capture the leaflets in a deliberate sequence rather than relying on uncontrolled contact. Precise handling supports alignment, helps secure the intended tissue, and reduces the risk of compromising leaflet motion. The resulting stability is important because successful grasping must both maintain the repair and reduce valve regurgitation.
The procedure begins by aligning the device with the affected valve under imaging guidance. The device then advances beneath the leaflets, captures and holds their tissue, and brings the leaflet edges together. The operator evaluates whether the capture is stable and whether valve motion remains acceptable. These steps support repositioning or repair during catheter-based treatment.
Leaflet grasping may be used during catheter-based treatment for selected patients with mitral or tricuspid valve disease, particularly when regurgitation results from inadequate leaflet coaptation. It offers a less invasive treatment option than approaches requiring more extensive access. The technique is relevant when clinicians seek to improve leaflet contact and reduce backward blood flow while preserving valve function.