Percutaneous Coronary Delivery
Percutaneous Coronary Delivery - Related Videos
08:20
Percutaneous Cricothyrotomy
0 Views •
2023
Source: James W Bonz, MD, Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA A surgical airway procedure is indicated when other forms of endotracheal intubation have failed and ventilation is worsening or not possible. This is the feared "can't intubate, can't ventilate" scenario, and in the emergency setting, cricothyrotomy is the surgical procedure of choice. Cricothyrotomy is preferred over tracheotomy because of the lower risk of complications, the predictable anatomy...
14:24
Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model
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Cited by 2 •
2018
Novel therapeutic strategies in cardiac regenerative medicine require extensive and detailed studies in large preclinical animal models before they can be considered for use in humans. Here, we demonstrate a percutaneous contrast echocardiography-guided intramyocardial injection technique in rabbits, which is valuable for hypothesis testing the efficacy of such novel therapies.
07:53
Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation
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Cited by 30 •
2015
We present a protocol to assess changes in neuromuscular function. Percutaneous electrical nerve stimulation is a non-invasive method that evokes muscular responses. Electrophysiological and mechanical properties of these responses permit the evaluation of neuromuscular function from brain to muscle (supra-spinal, spinal and peripheral levels).
06:39
Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
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Cited by 20 •
2015
Coronary flow reserve (CFR) is useful for assessment of myocardial oxygen demand and evaluation of cardiovascular risk. This study establishes a step-by-step transthoracic Doppler echocardiographic (TTDE) method for longitudinal monitoring of the changes in CFR, as measured from coronary artery in mice, under the experimental pressure overload of aortic banding.
07:36
Isolation of Mouse Coronary Endothelial Cells
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Cited by 18 •
2016
This protocol is prepared to share our method of isolating mouse coronary endothelial cells for the purpose of imaging or to conduct molecular biological experiments.
FAQs
Imaging guides catheter placement within the coronary arteries, allowing the clinician to position treatment near affected tissue rather than using a less targeted route. After placement, controlled injection or device deployment helps regulate where the therapeutic agent or device acts. This combination of visualization and controlled delivery supports localized coronary treatment without open surgery.
Placing treatment near affected coronary tissue can increase local exposure while limiting unnecessary distribution throughout the body. This distinction matters for therapies intended to act at a specific site, because the method concentrates treatment where it is needed rather than exposing all tissues equally. Reduced systemic effects are a potential advantage of this targeted strategy.
The approach reaches the coronary circulation through a catheter advanced inside a blood vessel, rather than requiring an open surgical route. Its minimally invasive character allows clinicians to deliver a device or therapeutic agent directly to a coronary target while imaging guides placement. This difference is especially relevant when localized treatment is desired without open surgery.
The approach can support several therapeutic categories, including coronary revascularization, localized drug delivery, and investigational cell or gene therapies. It can introduce either therapeutic agents or devices, depending on the treatment objective. This range makes the technique useful both for established coronary interventions and for studying newer treatments aimed at ischemic heart disease.
A clinician first advances a catheter through a blood vessel toward the coronary arteries. Imaging then guides and confirms its placement near the affected tissue. Once positioned, the clinician performs a controlled injection of a therapeutic agent or deploys a device. The sequence links vascular access, image-guided targeting, and localized treatment delivery.
It may be selected when treatment needs to reach a coronary location directly, particularly for revascularization or localized drug delivery. Researchers may also use it to investigate cell or gene therapies in ischemic heart disease. The method is therefore relevant both to clinical treatment strategies and to studies evaluating targeted therapies near affected coronary tissue.
By placing an intervention near affected coronary tissue, the method enables researchers to evaluate targeted therapeutic agents, devices, or investigational cell and gene therapies in a clinically relevant setting. Its controlled delivery and imaging guidance help connect the treatment location with the intervention being studied. This supports investigation of localized treatment strategies while limiting reliance on open surgery.