Pulmonary Blood Flow
Pulmonary Blood Flow - Related Videos
10:56
Automated Measurement of Microcirculatory Blood Flow Velocity in Pulmonary Metastases of Rats
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Cited by 2 •
2014
A method is presented to measure microcirculatory blood flow velocity in pulmonary cancer metastases of the pleural surface in rats in an automated fashion, using closed-chest pulmonary intravital microscopy. This model has potential to be used as a widespread tool to perform physiologic research on pulmonary metastases in rodents.
03:38
Developing a Cerebral Blood Flow Atlas for Blood Flow Mapping
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2025
Source: Tan, Z., et al., Construction and Application of Cerebral Functional Region-Based Cerebral Blood Flow Atlas Using Magnetic Resonance Imaging-Arterial Spin Labeling. J. Vis. Exp. (2024).This video demonstrates the method to construct a cerebral blood flow atlas by integrating magnetic resonance imaging or MRI-arterial spin labeling data with segmented brain regions, visualizing blood flow patterns, and quantifying flow levels across functional areas.
01:29
Blood Flow
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2025
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow. Slow...
09:23
Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension
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Cited by 15 •
2017
This protocol describes a surgical procedure to create a model for flow-induced pulmonary arterial hypertension (PAH) in rats and the procedures to analyze the principle hemodynamic and histological end-points in this model.
08:08
Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
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Cited by 5 •
2015
Pulmonary hypertension is associated with a significant reduction in pulmonary artery pulsatility, contractility and elasticity, contributing to an increase in pulmonary artery pressure and pulmonary resistance. Using a hypoxic piglet model, this study demonstrated that improving pulmonary artery plasticity using a newly developed pulsatile catheter improves hypoxic pulmonary hypertension.
FAQs
Gravity creates regional differences in how blood is distributed through the pulmonary circulation. Because this circulation operates at low pressure, gravitational effects and local vascular resistance influence perfusion across the lungs. These regional differences matter because oxygen uptake depends on how closely blood flow corresponds with ventilation, rather than on uniform perfusion alone.
Pulmonary vascular resistance determines how difficult it is for the right ventricle to move blood through the pulmonary circulation. The ventricle must generate enough pressure to maintain flow, while the normally low-pressure system supports efficient passage through pulmonary vessels and capillaries. Changes in resistance can therefore affect circulation and the effectiveness of gas exchange.
Ventilation-perfusion matching describes how well airflow reaches regions that receive pulmonary blood flow. When the two are appropriately aligned, blood can acquire oxygen and release carbon dioxide efficiently. Regional differences in either process can reduce that efficiency, making this relationship a central principle for understanding respiratory function and interpreting pulmonary abnormalities.
Clinicians interpret pulmonary blood flow alongside ventilation to evaluate ventilation-perfusion relationships. This assessment helps explain whether airflow and perfusion are sufficiently matched to support gas exchange. The relationship is particularly relevant when evaluating pulmonary embolism, pulmonary hypertension, heart failure, and respiratory disease, because each condition can alter or challenge normal pulmonary circulation.
Pulmonary blood flow provides an important framework for assessing both pulmonary embolism and pulmonary hypertension. The first is considered in relation to pulmonary perfusion, while the second concerns the pressure conditions of the pulmonary circulation. Examining these features helps clinicians connect circulatory changes with their potential effects on ventilation-perfusion relationships and gas exchange.
Assessment of pulmonary blood flow helps place heart failure and respiratory disease in a shared cardiopulmonary context. The pulmonary circulation links right ventricular output with lung gas exchange, so changes in flow, pressure, vascular resistance, ventilation, or perfusion may influence oxygen uptake and carbon dioxide removal. This makes pulmonary blood flow useful for interpreting disease-related impairment.