Lumbar Injection
Lumbar Injection - Related Videos
05:05
Laminotomy for Targeted Injection into the Lumbar Dorsal Root Ganglion in a Pig Model
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2025
Source: Unger, M. D., et al., Laminotomy for Lumbar Dorsal Root Ganglion Access and Injection in Swine. J. Vis. Exp. (2017)This video demonstrates a laminotomy procedure in an anesthetized pig to access the lumbar dorsal root ganglion for targeted neurotherapeutic delivery using convection-enhanced delivery.
05:24
In Vivo SiRNA Transfection and Gene Knockdown in Spinal Cord via Rapid Noninvasive Lumbar Intrathecal Injections in Mice
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Cited by 57 •
2014
This report describes a simple and rapid technique of intrathecal needle puncture for a localized transfection of siRNA in the lumbar spinal cord in mouse under short lasting light anesthesia.
04:41
Lumbar Intrathecal Injection of SOD1-ASOs for Precise CNS Targeting and Predictive Efficacy in Human SOD1-G93A ALS Mice
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2026
This article details intrathecal delivery methods for CNS-targeted therapeutics in adult mice, focusing on protocol precision and enabling repeated injection. It includes findings from a validation study where antisense oligonucleotides reduced mutant SOD1 expression in SOD1-ALS model mice, supporting the utility of the approach in preclinical research on neurodegenerative diseases.
03:02
Intrathecal Placement of Lumbar Drain: A Technique to Withdraw Cerebrospinal Fluid from the Lumbar Spine in Porcine Model
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2025
This video describes the technique of intrathecal placement of a lumbar drain in a porcine ischemic model, which helps in draining the cerebrospinal fluid to a drainage system. The cerebrospinal fluid pressure is monitored by the drainage system, and fluid is drained to maintain a constant cerebrospinal fluid pressure.
04:38
Intrathecal Vector Delivery in Juvenile Rats via Lumbar Cistern Injection
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2024
A surgical procedure is described to perform injections into the lumbar cistern of the juvenile rat. This approach has been used for the intrathecal delivery of gene therapy vectors, but it is anticipated that this approach can be used for a variety of therapeutics, including cells and drugs.
FAQs
The injection route determines which spinal structure receives the medication, while dose affects the amount available at that site. Tissue distribution then shapes how widely the agent acts beyond the intended target. Together, these pharmacologic factors influence both therapeutic response and diagnostic usefulness, helping explain why targeted delivery can produce local effects with less systemic exposure.
Local anesthetics temporarily reduce nerve signaling, which can help assess whether a selected spinal structure contributes to pain. Corticosteroids act on local inflammation and may support symptom management through a different mechanism. Using these agents in targeted locations allows clinicians to examine pain mechanisms while relating observed effects to the pharmacology of each medication.
The selected site links the medication’s action to a particular anatomic structure, such as the epidural space, a facet joint, or the region around a spinal nerve. A response at that location can provide information about possible pain mechanisms, whereas the same drug delivered elsewhere may produce a different therapeutic or diagnostic result.
Anatomical landmarks or imaging guidance help direct the needle toward the intended lower-spine structure. This targeting is important because the pharmacologic effect depends on where the medication is deposited. Accurate placement supports more meaningful diagnostic assessment and localized treatment, while also helping clinicians relate the administered dose and route to the resulting clinical response.
They are used when researchers or clinicians need to study targeted drug delivery, pain mechanisms, or the relationship between an administered agent and a selected spinal structure. The approach can provide both management and diagnostic information, making it useful for evaluating how route, dose, tissue distribution, and drug action shape outcomes in the lower spine.
Evaluation can include temporary reduction in nerve-related signaling, improvement associated with reduced local inflammation, or information about whether the targeted structure contributes to pain. These outcomes connect observed symptoms with the medication’s action and delivery site. They also help illustrate how localized administration may limit systemic drug exposure while still producing clinically relevant effects.