Stellar Collapse

Stellar collapse is the rapid contraction of a star or stellar core when internal pressure can no longer balance gravity, a process that drives some of the universe’s most energetic events. As fuel is exhausted or a massive core loses pressure support, gravity compresses matter, raising density and temperature until electron capture, nuclear reactions, and, in extreme cases, neutron degeneracy or relativistic effects determine the remnant’s evolution. In physics, studying stellar collapse explains core-collapse supernovae, neutron-star and black-hole formation, and the production or redistribution of heavy elements. Observations of neutrinos, gravitational waves, and explosive light provide tests of dense-matter physics and stellar evolution.

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Research

JoVE EoE - Neuropathology

In Vitro Assessment of Aggregated Amyloid-β on Neuronal Growth Cone Collapse

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2025

This video demonstrates an in vitro assessment of neuronal growth cone collapse by amyloid-β (Aβ) aggregates. Treating the neurons with Aβ aggregates causes cytoskeletal destabilization, leading to the collapse of growth cones at the tip of the axons. The treated cells are compared with control cells to assess the extent of growth cone collapse.

Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons

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Cited by 4 •

2018

Here a protocol to investigate the early effects of amyloid-β (Aβ) in the brain is presented. This shows that Aβ induces clathrin-mediated endocytosis and collapse of axonal growth cones. The protocol is useful in studying early effects of Aβ on axonal growth cones and may facilitate prevention of Alzheimer's disease.

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

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Cited by 1 •

2009

A novel microfluidic system has been developed using the phenomenon of passive pumping and a user controlled fluid delivery system. This microfluidic system has the potential to be used in a wide variety of biological applications given its low cost, ease of use, volumetric precision, high speed, repeatability and automation.

Rapid, Seamless Generation of Recombinant Poxviruses using Host Range and Visual Selection

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Cited by 11 •

2020

This is a method to generate “scarless” recombinant vaccinia viruses using host-range selection and visual identification of recombinant viruses.

Three-Dimensional Culture Assay to Explore Cancer Cell Invasiveness and Satellite Tumor Formation

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Cited by 4 •

2016

Cancer cells are embedded in a collagen gel and then sandwiched in an acellular fibrin gel to generate a 3D culture system in which the invasiveness and formation of satellite tumors may be monitored.

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