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Immunology and Infection

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JoVE Journal Immunology and Infection
The Utilization of Oropharyngeal Intratracheal PAMP Administration and Bronchoalveolar Lavage to Evaluate the Host Immune Response in Mice
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The Utilization of Oropharyngeal Intratracheal PAMP Administration and Bronchoalveolar Lavage to Evaluate the Host Immune Response in Mice

Article DOI: 10.3791/51391-v • 12:27 min • April 2nd, 2014
April 2nd, 2014 •
1
1Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University

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The host immune response to pathogen infection is a tightly regulated process. Utilizing a lipopolysaccharide lung exposure model in mice, it is possible to conduct high resolution evaluations of the complex mechanisms associated with disease pathogenesis.

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Oropharyngeal Intratracheal PAMP Administration Bronchoalveolar Lavage Host Immune Response Mice Intraperitoneal Injections Pathogens Pathogen Associated Molecular Patterns (PAMPs) Infectious Disease Pathobiology Lung Acute Lung Inflammation Model Lipopolysaccharide (LPS) Nonsurgical Oropharyngeal Intratracheal Administration Clinical Parameters Disease Pathogenesis Bronchoalveolar Lavage Fluid Host Innate Immune Response Allergic Airway Inflammation Pharmacological Applications
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