Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators

Henrik Sund&#233;n; Linda Ta; Anton Axelsson

doi:10.3791/53213

/

Síntesis altamente estereoselectiva de 1,6-cetoésteres Mediada por líquidos iónicos: una reacción de tres componentes Habilitación de acceso rápido a una nueva clase de bajo peso molecular gelificantes

Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators

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Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators

Síntesis altamente estereoselectiva de 1,6-cetoésteres Mediada por líquidos iónicos: una reacción de tres componentes Habilitación de acceso rápido a una nueva clase de bajo peso molecular gelificantes

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9,601 Views

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06:31 min

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November 27, 2015

DOI:

10.3791/53213-v

DOI:

10.3791/53213-v

•

06:31 min

November 27, 2015

•

9580 Views

Henrik Sundén¹, Linda Ta¹, Anton Axelsson¹

¹Chemistry and Chemical Engineering,Chalmers University of Technology

Summary

Ionic liquids (ILs) mediate fast, simple and cheap access to 1,6-ketoesters in high diastereoselectivities and good yields. The reaction protocol is robust and the 1,6-ketoesters can be obtained in gram scale after a simple filtration protocol. Moreover, the 1,6-ketoesters are potent gelators in hydrocarbon solvents.