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En flöde flödescytometri-baserad analys identifiera föreningar som stör bindningen av Fluorescently-märkta CXC Chemokine Ligand 12 till CXC Chemokine Receptor 4

Article DOI: 10.3791/57271-v • 06:56 min • March 10th, 2018
March 10th, 2018 •
1, 1, 1, 1, 1
1Laboratory of Virology and Chemotherapy, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven

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Ett flöde flödescytometri-baserade cellulära bindande analys beskrivs som används främst som en screeningmetod för att identifiera substanser som hämmar bindningen av en fluorescently märkt CXC chemokine ligand 12 (CXCL12) till CXC chemokine receptorn 4 (CXCR4).

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Molekylärbiologi fråga 133 G-proteinkopplade receptorn CXC chemokine receptor 4 märkt fluorescently chemokine ligand 12 flödescytometri cell-baserad analys receptorbindning läkemedelsutveckling små molekyler Jurkat celler
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