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Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery

Article DOI: 10.3791/58527-v • 08:09 min • August 6th, 2019
August 6th, 2019 •
*1, *2, 2, 3, 2, 3, 1, 2
1Research Center of Clinical Oncology, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Nanjing Medical University Affiliated Cancer Hospital, 2Department of General Surgery, The First Affiliated Hospital with Nanjing Medical University, 3School of Clinical Medicine, Xuzhou Medical University
* These authors contributed equally

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This work presents the preparation of methionine functionalized biocompatible block copolymers (mBG) via the reversible addition-fragmentation chain transfer (RAFT) method. The plasmid DNA complexing ability of the obtained mBG and their transfection efficiency were also investigated. The RAFT method is very beneficial for polymerizing monomers containing special functional groups.

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Methionine Functionalized Biocompatible Block Copolymers Targeted Plasmid DNA Delivery Cationic Polymer Drug Carriers Stability Immunogenicity Facile Preparation Modification Reversible Addition-fragmentation Chain Transfer Polymerization Controlled Molecular Weight Functional Groups Collaborate Treatment Cancer Inflammation Diseases IFT Polymerization Gene Therapy Reaction Temperature Control Oil Bath Water Bath Round-bottom Flask Rubber Stopper Magnetic Stirrer Polymerization Bottle Bis-hydroxy HEMA Distilled Water Beaker CTP ACVA 1 4-dioxane
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