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Murine Model of Metastatic Liver Tumors in the Setting of Ischemia Reperfusion Injury

Article DOI: 10.3791/59748-v • 05:59 min • August 30th, 2019
August 30th, 2019 •
1, 1
1Department of Surgery, University of Pittsburgh

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We describe in detail a clinically relevant colorectal cancer liver metastases (CRLM) tumor model and the influence of liver ischemia reperfusion (I/R) in tumor growth and metastasis. This model can help to better understand the mechanisms underlying surgery-induced promotion of liver metastatic growth.

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Murine Model Metastatic Liver Tumors Ischemia Reperfusion Injury Liver Surgery Bleeding Septic Shock Tumor Growth Clinical Setting C57 Black 6 Mouse Abdominal Wall Skin Disinfection Midline Incision Abdominal Muscle And Peritoneum Spleen Exposure Cancer Cell Suspension
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