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JoVE Journal Neuroscience
Intratekal levering av Antisens Oligonukleotider i Rat Central nervesystemet
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Intratekal levering av Antisens Oligonukleotider i Rat Central nervesystemet

Article DOI: 10.3791/60274-v • 07:47 min • October 29th, 2019
October 29th, 2019 •
*1, *2, *1, 1, 1, 1, 1
1Biogen, Inc., 2Ionis Pharmaceuticals
* These authors contributed equally

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Her beskriver vi en metode for å levere narkotika til rotte sentralnervesystemet ved å implanting et kateter inn i korsryggen intratekal plass i ryggraden. Vi fokuserer på levering av antisens oligonukleotider, men denne metoden er egnet for levering av andre terapeutiske modaliteter også.

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Nevrovitenskap antisens oligonukleotider blod hjerne barriere sentralnervesystemet intratekal levering rotte RNA ryggmargen
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