Pruebas de terapias dirigidas en cáncer mediante análisis de alteración estructural del ADN y xenoinjertos derivados del paciente
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July 25, 2020
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Aquí presentamos un protocolo para probar la eficacia de las terapias dirigidas seleccionadas en base a la composición genómica de un tumor. El protocolo describe la identificación y validación de reordenamientos estructurales del ADN, injerto de tumores de los pacientes en ratones y pruebas de respuestas a los fármacos correspondientes.
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Zhang, P., Kovtun, I. V. Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts. J. Vis. Exp. (161), e60646, doi:10.3791/60646 (2020).
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