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A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

Article DOI: 10.3791/61740-v • 09:42 min • June 4th, 2021
June 4th, 2021 •
1, 2, 2
1Department of Anesthesiology, Taipei Veterans General Hospital, National Yang-Ming University School of Medicine, 2Department of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia School of Medicine

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Resumen
Automatic Translation

Traditional photothrombotic stroke (PTS) models mainly induce dense platelet aggregates of a high resistance to tissue plasminogen activator (tPA)-lytic treatment. Here a modified murine PTS model is introduced by co-injecting thrombin and photosensitive dye for photoactivation. The thrombin-enhanced PTS model produces mixed platelet:fibrin clots and is highly sensitive to tPA-thrombolysis.

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Fibrin-enriched Stroke Model TPA-sensitive Stroke Model Thromboembolic Stroke Model Surgical Procedures Infarction Size And Location Platelet:fibrin Intermixed Blood Clots Fibrinolytic Treatment RB Dye-based Photothrombotic Stroke Model Lytic Treatment Clot Composition Thrombin And RB Combined Photothrombosis Model Mixed Platelet:fibrin Blood Clots Infarct Sizes And Locations Mortality Alteplase Novel Thrombolytic Therapies
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