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Immunology and Infection
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JoVE Journal Immunology and Infection
Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus)
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Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus)

Article DOI: 10.3791/62317-v • 13:00 min • July 31st, 2021
July 31st, 2021 •
1,2, 1, 2, 2,3,4
1Division of Laboratory Animal Resources, Duke University Medical Center, 2Department of Pathology, Duke University Medical Center, 3Department of Immunology, Duke University Medical Center, 4Duke Human Vaccine Institute, Duke University Medical Center

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This article describes and demonstrates the administration of intranasal vaccines and the collection of milk from lactating rabbits (Oryctolagus cuniculus) as a means to assess mucosal immunity in a translationally appropriate model of maternal immunization.

Tags

Intranasal Immunization Maternal Immunization Antibody Transfer New Zealand White Rabbits Placentation Mucosal Maternal Immunization Intramuscular Immunization Blood Collection Antigen-specific IgG Levels Breeding Rabbits Pregnancy Rate
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