Waiting
Procesando inicio de sesión ...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Chemistry / Constructing Cyclic Peptides Using an On-Tether…
JoVE Journal
Chemistry

Se requiere una suscripción a JoVE para ver este contenido.

JoVE Journal Chemistry
Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
A Technical Guide for Performing Spectroscopic Measurements on Metal-Organic Frameworks
Journal (Chemistry)
A Technical Guide for Performing Spectroscopic Measurements on Metal-Organic Frameworks
Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates
Journal (Chemistry)
Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates
 

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Article DOI: 10.3791/64289-v • 07:11 min • September 28th, 2022
September 28th, 2022 •
*1, *1,2, *1, 3, 1,2, 1, 3, 1,2, 1,2
1Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, 2Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, 3Department of Radiation Oncology, the First Affiliated Hospital, Anhui Medical University
* These authors contributed equally

Capítulos

Resumen
Automatic Translation

This protocol presents the synthesis of cyclic peptides via bisalkylation between cysteine and methionine and the facile thiol-yne reaction triggered by the propargyl sulfonium center.

Tags

Cyclic Peptides On-tether Sulfonium Center Sulfonium Salt Fast Reaction Efficient Method Peptide Stabilization N-terminal Deprotection Solution Piperidine Morpholine DMF Vacuum Pump Dichloromethane N,N-dimethylformamide Resin Color Detection Coupling Of Peptides Polypropylene Tube N,N-diisopropylethylamine N,N'diisopropylcarbodiimide
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter