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JoVE Journal Cancer Research
Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer
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Journal (Cancer Research)
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Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer

Article DOI: 10.3791/64629-v • 06:49 min • February 10th, 2023
February 10th, 2023 •
1, 1, 2, 1,3
1Stem Cells and Cancer Laboratory, Vall d’Hebron Institute of Oncology (VHIO), 2Preclinical Therapeutics Core, University of California San Francisco, 3CIBERONC

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This protocol describes the orthotopic implantation of patient-derived cancer cells in the cecum wall of immunodeficient mice. The model recapitulates advanced colorectal cancer metastatic disease and allows for the evaluation of new therapeutic drugs in a clinically relevant scenario of lung and liver metastases.

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Orthotopic Implantation Patient-derived Cancer Cells Mice Advanced Colorectal Cancer Preclinical Models 3D Tumoroids Tumor Organoids Cancer Drug Screening Drug Resistance Mechanisms Metastatic Disease Anti-cancer Therapies In Vivo Models Molecular Features Human Cancer Metastasis Orthotopic Model Cecum Wall Injection Primary Tumors Liver Metastasis Lung Metastasis CRC Mouse Model Drug Responses Microcomputed Tomography (µCT) Surgical Procedure Immunodeficient Mice
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